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NO IMAGE AVAILABLE |
Rat Blood Pressure
- Wins
Mac
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Multi-User Educational |
Shipped in 2 days |
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Cat.# SB-31 |
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Multi-User Non-Educational |
Shipped in 2 days |
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Cat.# SB-31NE |
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An interactive computer
simulation of experiments to study the effects of a number of
pharmacological agents on rat blood pressure in vivo
This highly interactive program simulates a range of
experiments to demonstrate the effects of a variety of pharmacological
agents/procedures on blood pressure and heart rate of the anaesthetized
rat (in vivo). It is aimed at undergraduates studying pharmacology modules
on a range of medical and science courses. Each section combines text,
high quality colour graphics, and animation with interactive questions
designed to reinforce learning.
The main menu allows students to access sections covering different
aspects of the laboratory class;
Introduction: Home Office Licence requirements,
Preparation: anaesthesia/anaesthetization, cannulation of trachea,
jugular vein and carotid artery,
Apparatus: equipment used to maintain body temperature, record
blood pressure and heart rate,
Measurements: describes how to take measurements from the simulated
chart recorder and how to calculate mean BP and pulse pressure,
Experiments: provides typical data for 16 different experiments selected
to teach the essential pharmacology: catecholamines; pressor agents;
acetylcholine; ganglion stimulants; uptake1-blockers; alpha-blockers;
beta-blockers; adrenaline reversal; guanethidine; sympathetic nerve
stimulation; depressor drugs; ganglion blockade; quantitative effects of
alpha-blockade; quantitative effects of beta-blockade; reserpine; pithing
Students are expected to record and tabulate data from the screen display
and to then complete student assignments e.g. a series of MCQ questions,
with feedback, to assess accuracy of data collection and data
interpretation; a student task (typical of a traditional lab-class report)
to be completed in their own time. In addition there is a section
containing a selection of MCQ's with feedback covering cardiovascular
pharmacology which students can use for revision.
STUDENT PRICING
NOW AVAILABLE FOR THIS PRODUCT
CLICK HERE
TO GO TO THE STUDENT SECTION
| System Requirements:
Windows: Intel Pentium II
450MHz or faster processor (or equivalent), 128MB of RAM; Microsoft
Windows 98, Windows Me, Windows 2000, Windows XP or Windows Server
2003 Macintosh:
PowerPC G3
500MHz or faster processor, 128MB of RAM; Mac OS X v.10.1.x, 10.2.x,
10.3.x, or 10.4.x Recommended browser software:
Windows:
Internet Explorer; Macintosh: Safari or Firefox; Both: Adobe Flash
Player plug-in, version 8 or higher.
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Langendorff
Heart
- Wins
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Multi-User Educational |
Shipped in 2 days |
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Cat.# SB-16 |
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Multi-User Non-Educational |
Shipped in 2 days |
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Cat.# SB-16NE |
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| Screenshot_1 |
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| To View a Flash Demo CLICK HERE (Duration:
2 mins 10 secs, Size: 1MB) |
A
computer simulation of experiments which may be
performed
on the isolated, perfused mammalian heart
This program is highly interactive and
simulates experiments, which may be performed on
the isolated perfused mammalian heart (Langendorff
preparation).
Introduction and Methods sections
cover the removal of the heart , setting it up to
record ventricular contractile force, heart rate
and coronary blood flow and the administration of
drugs.
In the Experiments section simulated data,
derived from actual data, is presented on a screen
display which emulates a chart recorder. Students
'design' experiments by choosing, from a menu, a
range of pharmacological agents which may be
administered either alone, or in combination with
an antagonist or potentiator. Each trace
represents several minutes of recording and thus
allows students to access a large amount of data
in a short period of time. A facility to compare
traces of 'drug X alone' with drug X + antagonist
Y or drug X + potentiator Z is available. This
allows easy visual comparison of qualitative
effects and of course more accurate measurements
can be taken from the screen.
The program covers:
1. Effects of drugs: sympathomimetics
(adrenaline, noradrenaline, salbutamol, clonidine,
phenyl-ephrine, dobutamine) antagonists
(propranolol, yohimbine atenolol, prazosin,
butoxamide, phentolamine) potentiators (cocaine);
parasympathomimetics (acetylcholine, carbachol,
methacholine, nicotine) antagonists (atropine,
amitryptyline, hexamethonium) potentiator
(neostigmine); cardiac glycosides (digoxin,
ouabain); coronary vasodilators (nitrogly-cerine,
adenosine (antagonists: theophylline,
dipyridamole), histamine (antagonists: cimetidine,
mepyramine), verapamil;
2. Effect of ions: (high and low
concentrations of calcium, potassium and sodium);
3. Effect of increasing pre-load on contractile
(ventricular) force (Starlings Law).
The simulated responses (heart rate,
ventricular force and coronary blood flow) are
derived from actual experimental data and
presented in high resolution colour graphics in a
form comparable to that of a chart recorder.
The
program contains textual information describing
the preparation and experimental method and an
editable on screen help facility allows teachers
to tailor the information-content of the program
to specific groups of students. The package also
includes suggested student assignments.
It is envisaged that the program could be used
in a number of ways: to better prepare students
who will the perform the practical at a later
date; to debrief students after they have
performed the practical; as a ‘fallback’ to
provide data for students whose experiments were
unsuccessful; as an alternative to the practical,
though it should be remembered that different
learning objectives may be achieved.
STUDENT PRICING
NOW AVAILABLE FOR THIS PRODUCT
CLICK HERE
TO GO TO THE STUDENT SECTION
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System Requirements: IBM
PC's running Windows, CD-ROM drive. |
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| To View a Flash Demo CLICK HERE (Duration:
2 mins 50 secs, Size: 1.4MB) |
A
computer simulation of experiments which may
be performed on the superior
cervical ganglion-nictitating membrane
preparation of the cat in vivo
An interactive, menu driven program which
simulates experiments on the superior cervical
ganglion-nictitating membrane preparation of
the cat (in vivo) to teach the pharmacology of
ganglionic transmission and sympathetically
innervated smooth muscle.
Introduction: provides information
about the program and it's curricula
context;
Tutorial:
presents diagrammatic
representations of the effector junction and
the superior cervical ganglion. This section
of the program uses animated sequences to
demonstrate the stages of transmission at both
the synapse and neuro-effector junction and
highlights possible sites of action of drugs;
Methods: describes the preparation,
protocols for nerve stimulation and
administration of drugs to the superior
cervical ganglion and the nictitating
membrane, and the method of recording
contractions of the nictitating membrane.
Experiments: allows students to
perform simulated experiments on the
preparation and provides recordings of the
force of contraction of both ipsilateral and
contralateral nictitating membranes which are
displayed on a screen designed to emulate a
chart recorder. A sub-menu gives students some
control over experimental parameters (they can
choose: 1. to administer an agent from a list:
saline (vehicle control), acetylcholine,
noradrenaline, atropine, phentolamine,
propranolol, isoprenaline, hexamethonium,
physostigmine, nicotine (low and high dose),
tyramine, an unknown (which is randomly
selected from the list above when the program
is run); 2. the site of administration; 3.
whether to electrically stimulate
preganglionic nerves (half-maximal
stimulation).
Although it is envisaged that the tutor
will develop a set of tasks for students to
address when using the simulation which will
meet their own teaching objectives, this
section does also includes some suggested
tasks to aid independent use of the program.
STUDENT PRICING
NOW AVAILABLE FOR THIS PRODUCT
CLICK HERE
TO GO TO THE STUDENT SECTION
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System
Requirements: IBM PC's running
Windows 95, or better, CD-ROM drive.
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This CD-ROM provides an introduction to the fundamental
principles of the anatomy of the ANS. It demonstrates the
effects on organ function and describes the pharmacology
of drugs that interact with autonomic neural function. The
program allows students to approach the subject from three
directions relating to the key areas of anatomy,
neurotransmitter (drawing largely on pharmacology and
biochemistry) and organ system (physiology and
pharmacology).
Anatomy covers the division of the ANS into sympathetic,
parasympathetic and enteric systems.
The neurotransmitters (acetylcholine, catecholamines,
opioids) allow a different point of access and link to the
other sections to allow students to see where the
transmitters occur and what effects they have.
The third section, organ systems, demonstrates the actions
of the different divisions of the ANS at a tissue level.
Organs are grouped by systems (initially restricted to
cardiovascular, respiratory, gastrointestinal and eye)
consistent with an integrated systems based curricula
(medicine, dentistry, physiotherapy) but also relates well
to areas of specialisation in other courses (eg
optometry).
By using a search engine, students are able to access
material in order to obtain both general overviews and
specific interactions between anatomy, neurotransmitter
and organs within the ANS. The multiple options for access
make the program flexible so that students at different
stages of the course can select to use those components of
the program that complement their current learning
objectives.
Authors: Owen Woodman, James Ziogas, Colin
Anderson, Gregor Kennedy
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System Requirements: Macintosh:
Mac: OS system 8.6 or greater. Powermac, G3 or better. Total RAM 64 or
greater. Millions of colours. 800 x 600 minimum display.
Windows:
Windows 95/98/ME/2000/NT/XP. 24 bit colour and 32Mb of RAM.
800 x 600 minimum display. Quicktime 4. |
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Contact us for
multi-user pricing |
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This program was developed to demonstrate the
components and processes involved in the transfer of
oxygen and carbon dioxide between the lungs and tissues.
Gas exchange is fundamental to life and a detailed working
knowledge of O2/CO2 transfer is central to respiratory
medicine. The program provides a learning map for students
by following the progress of an inhaled oxygen molecule as
it crosses the lung alveolar membrane, binds to
haemoglobin, transfers to tissues down concentration
gradients and finally exists as CO2.
The purpose of the program is to provide a core of
knowledge represented by the path of O2. Students are able
to use a flexible, interactive teaching program to
encourage deeper exploration of the science of gas
transfer. Special emphasis is given to developing
clinically oriented patient scenarios where the
consequences of impaired gas exchange manifest as human
disease.
Authors: Assoc Prof Lou Irving, Assoc Prof Gary
Anderson
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System Requirements: Windows:
Microsoft Windows Platforms, 450 MHZ Intel Pentium II processor (or
equivalent) and later, 256 MB RAM, Win 2000, Win XP, Screen Resolution
800*600, Sound Card, Video Card, Plug-ins.
Macintosh:
Screen Resolution 800 x 600, 500 MHZ Power PC G3 and later, 256 MB RAM,
OS 10.1.5, 10.2.8, OS 10.3.9, 10.4, Sound Card, Video Card, Plug-ins. |
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| To View a Flash Demo CLICK HERE (Duration:
2 mins 15 secs, Size: 2.2MB) |
A
computer simulation of experiments to demonstrate
the effects of pharmacological
agents on the cutaneous inflammatory response in
the anaesthetised rabbit
This program simulates a range of experiments
designed to demonstrate the action of inflammatory
mediators and pharmacological agents on the in
vivo inflammatory response in the anaesthetised
rabbit. The program uses data obtained from actual
experiments and is aimed at undergraduate students
on courses in which pharmacology is a major
component. It may be particularly useful for
teaching students either to support laboratory
practicals or, in those departments where lack of
equipment and/or technical expertise precludes
this, as a student-centred alternative.
Introduction and Methods sections combine text
and high- quality colour graphics to describe the
animal preparation, the methods employed to
measure oedema formation (extravascular
accumulation of 125I - albumin) and neutrophil
accumulation, and to provide the student with the
essential background information required to
understand the how the inflammatory response is
triggered, and the mechanisms involved.
The Experiments section allows the student to
select, from a menu, to study the effects of the
following agents on oedema formation (and where
appropriate on neutrophil numbers) in normal
rabbits:
1. A range of direct mediators of increased
microvascular permeability [histamine,
bradykinin, platelet activating factor (PAF),
Substance P, leukotriene D4], either
alone (dose-response relationships), in the
presence of a vasodilator (PGE2) or
with receptor antagonists;
2. A range of agents which cause inflammation
principally via neutrophil accumulation
[complement Factor C5a, cytokines interleukins
IL-1 and IL-8, the bacterial peptide
f-methyl-leucyl-phenylalanine (FMLP),
leukotriene B4, Tumour Necrosis Factor (TNFalpha)],
either alone (dose-response relationships) and
in the presence of a vasodilator (PGE2).
The effects of neutrophil depletion and the
importance of adhesion molecules are also
covered;
3. Non-steroidal (local and systemic effects)
and steroidal anti-inflammatory agents.
A section describing the results of selected
experiments using sensitised rabbits is also
included and covers the IgG (Reverse Passive
Arthus response) and IgE response.
The results are presented in graphical form
either as bar-charts or line graphs. The program
contains numerous self-assessment exercises which
demand interpretation of experimental data
presented to them, and an understanding of the
underlying inflammatory mechanisms. These
student-centred activities make the program useful
for self-directed learning or, in the ideal
situation, it would be incorporated into a
structured teaching programme and used with a
teacher-designed workbook.
STUDENT PRICING
NOW AVAILABLE FOR THIS PRODUCT
CLICK HERE
TO GO TO THE STUDENT SECTION
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System Requirements: Pentium
PC, Windows 95/98/NT4, 16 MB RAM minimum, 16 bit
colour graphics, CD-ROM drive. |
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Experimental
Design
- Wins
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Single User |
Shipped in 2 days |
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Cat.# SB-9 |
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Multi-User Educational |
Shipped in 2 days |
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Cat.# SB-9SL |
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To View a Flash Demo CLICK HERE (Duration:
3 mins 10 secs, Size: 8.2MB)
Allow several minutes for this Demo to download |
A
highly interactive computer based learning package
to
teach better experimental design
'Experimental Design’ aims to help
researchers, particularly those working with
animals, to design more effective experiments
which will deliver more information, produce more
conclusive results, improve interpretation and
reduce the number of experimental animals
required. It combines real life scenarios, working
examples and background theory and throughout the
student learns by exploration and engages in
interactive practical exercises that give hands on
exposure to the key concepts in experimental
design. The program has been designed with the
close collaboration of research scientists in
industry and academia. In addition, members of the
scientific community ranging from post-graduates
to project leaders have evaluated the software to
ensure the appropriateness of its content.
Aims: to enable the research scientist
to:
- estimate the number of animals needed to
attain the scientific objectives economically
and effectively.
- select a suitable animal model
- avoid bias and deal with variability
- use appropriate statistical methods or more
effectively consult professional statisticians
Sections exploring the key issues in
experimental design are accessed from a menu.
- Introduction & Aims - primes the
user as to why experimental design is so
critical. Engages the user with data from a
simple experiment to highlight design flaws.
- Choice of Animal Model - explores the
use different strains (inbred and outbred
stock) and covers the various types of animal
model (predictive, explanatory, exploratory).
- The Experimental Unit - uses
interactive examples to explain the critical
nature of the experimental unit and it's
importance.
- Eliminating Bias - covers techniques
you can employ to remove systematic
differences between treatment groups and
ensure your experiments are not biased. Again
interactive examples are used
- Applying Valid Statistics - covers
the application of valid statistical tests to
your data, explores the definition of
hypotheses, choices of statistical tests, and
interpretation of P.
- Improving Precision - making
experiments more precise so that we can detect
treatment differences. Ways of achieving this
- ensuring uniformity, use of blocking, using
power analysis and the resource equation
method.
- Increasing the Range of Applicability - using
your resources effectively to enable you to
interpret your findings over a wider range
e.g. different treatments, different strains,
sexes, sizes. Use of multi-factorial design.
- Planning and Organising - key issues
in designing and analysing effective (simple)
experiments.
- Self-Assessment Activity - series of
case studies and true/false questions with
feedback to self-assess your understanding.
- Software Tools & References - where
to get further information.
STUDENT PRICING
NOW AVAILABLE FOR THIS PRODUCT
CLICK HERE
TO GO TO THE STUDENT SECTION
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System Requirements: PC
(minimum specification: 166 MHz Intel Pentium II
processor, Windows 95/98/NT4, 32 MB RAM, 16 bit
colour graphics), CD-ROM drive. |
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PK-SIMS
- Wins
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Multi-User Educational |
Shipped in 2 days |
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Cat.# SB-22 |
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Multi-User Non-Educational |
Shipped in 2 days |
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Cat.# SB-22NE |
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Screenshot_1 |
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| To View a Flash Demo CLICK HERE (Duration:
1 min 30 secs, Size: 370KB) |
An
interactive pharmacokinetic simulation program
which presents
graphical displays of the
relationship between dosage
regimen and drug
plasma levels
An easy-to-use, menu-driven program, which
allows the user to investigate the pharmacokinetic
relationships between the dose regimen of a drug
administered to an individual, and the blood
plasma concentration. A number of parameters may
be selected:
1. The individual may be "normal",
suffering from severe liver damage or suffering
severe kidney failure;
2. A range of drugs are available: ampicillin,
digoxin, propranolol, phenytoin, diazepam,
lignocaine, quinidine, gentamicin, paracetamol.
3. Different routes of administration: single
i.v. dose, single oral dose, repeated i.v. dose,
repeated oral dose, continuous i.v. infusion,
single sub-cutaneous dose, single i.m. dose.
4. Different dosage regimen: size of the drug
dose, duration of the investigation, dose
interval, size of any loading dose administered,
Once the program parameters have been selected,
the program will calculate the drug plasma
concentrations and present, on-screen, a variety
of graphical (plasma concentration of drug
(y-axis) against time (x-axis) using either linear
x-y axes or log y linear x-axes) or numerical
outputs. The display also shows recommended upper
and lower plasma concentration levels for the
chosen drug.
The program is aimed at students of
pharmacology on a variety of undergraduate courses
e.g. medicine, dentistry and biomedical sciences.
The program is supported by printed student-centred
exercises.
STUDENT PRICING
NOW AVAILABLE FOR THIS PRODUCT
CLICK HERE
TO GO TO THE STUDENT SECTION
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System Requirements: Windows
95, and above, CD-ROM drive. |
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Mac
