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Haemophilia and Haemostasis: A Case-based Approach to Management by Harold Ross Roberts Hardcover - 256 pages Shipped in CLICK HERE Cat.# JW-HEM3 $120.90 BUY Published:  2007   ISBN:  9781405167161

This unique book covers the major cases one might encounter in diagnosing, managing and treating haemophilia. It will provide a practical and informative guide to the broad range of topics concerning both bleeding and clotting disorders.

Haemophilia and Haemostasis: A Case-based Approach to Management is divided into major chapter sections by disorder. Each chapter contains questions and cases that were originally submitted to the online Haemostasis-forum (previously Haemophilia-forum). Cases and questions associated with each disorder are presented alongside practical answers from a wide range of international contributors.

Practical, clinical questions, answered by the world's leading experts

• All case studies gathered from the Archives of the Haemostasis/Haemophilia Forum – 1997-2006
• Covers haemophilia, Von Willebrand Disease and many other bleeding and clotting disorders
• Over 80 case studies with practical answers
• To reflect varying practice, controversial areas will be clearly marked and discussed throughout

Whether you are a practising clinician or trainee in haematology, working in the fields of coagulation, haemostasis or thrombosis, or any other health care professional working in a haemophilia centre, this book will provide practical clinical answers to aid in your day to day patient care.

Table of Contents:

List of Haemostasis Forum Editors
List of Contributors
Preface

1. Hemophilia A and Hemophilia B

General Overview
Hemophilia and Immune Tolerance Therapy
The Hemophilic Ankle: An update
The Hemophilic Knee: An update
Issues with Complicated Diagnoses
Combined Hemophilia A and B Carrier
A Complex Case of Hemophilia with HIV and Hepatitis C
A Case of Hemophilia B, Mild VWD and a Factor IX Inhibitor
Premature Infant with Hemophilia B
Hemophilic Carriers
Hemophilic Carriers and Delivery
Mild Hemophilia in Women
Treatment of the Pregnant Hemophiliac
Anticoagulation and Hemophilia
Anticoagulation for Atrial Fibrillation in a Hemophiliac
Anticoagulation for a Cardiac Valve in a Hemophiliac
Cardiac Catheterization in a Hemophiliac
Anticoagulation for a DVT in a Hemophiliac
Treatment of Hemophiliacs
DDAVP for Treatment of Mild Hemophilia during Surgery
Hemophilia and Hemodialysis
Hemophilia and Hepatitis C Treatment
Hemophilia and Physical Therapy
Hemophilia and Renal Bleeds
Hemophilia and SCUBA Diving
Hemophilia and Ventricular Septal Defect Repair
Hemophilia with Hepatitis C and Recurrent Bleeding
Isotretinoin in Hemophilia
Laser Eye Surgery in a Hemophiliac
Managing Hemophilic Pseudotumors
Continuous NovoSeven: Pros and Cons
Complications of Treatment
Hemophilia B and Immune Tolerance with Anaphylaxis
NovoSeven (rFVIIa) and DIC
Thrombosis in Prothrombin Complex Concentrates (PCCs) vs. activated Prothrombin Complex Concentrates (APCCs)

2. Von Willebrand Disease (VWD)

Epidurals and VWD
Anticoagulation for a Cardiac Valve in a patient with VWD type 1
VWD type 2a and Pregnancy
VWD type 2b and Pregnancy
VWD type 2b Versus Platelet Type
Prophylaxis in VWD type 3
Platelet Type VWD

3. Factor Deficiencies

Combined Factor V and VIII Deficiency
DVT Prophylaxis in FVII Deficiency
Menorrhagia in Factor VII Deficiency
Anticoagulation for Atrial Fibrillation in FX Deficiency
Management of Factor X Deficiency
Anticoagulation for Atrial Fibrillation in a patient with Factor XI Deficiency
Factor XI Deficiency and Surgery
Prophylaxis for Patients with Factor XIII Deficiency and Intracranial Bleeding

4. Rare Platelet and Coagulation Disorders

Coagulation Disorders
Afibrinogenemia
Dysfibrinogenemia
Hypofibrinogenemia
Gardner-Diamond Syndrome
Hereditary Hemorrhagic Telangiectasia (HHT)
Hereditary Vitamin K Dependent Coagulation Factors Deficiency and Pregnancy
Platelet Disorders
Glanzmann’s Thrombasthenia and Gastrointestinal Angiodysplasia
Glanzmann's Thrombasthenia and Pregnancy
NovoSeven and Wiscott-Aldrich

5. Acquired Bleeding Diatheses

Acquired Hemophilia and Second Pregnancy
Developing a Factor IX Inhibitor
Acquired Bleeding Diatheses: End-Stage Liver Disease and Surgery
Treatment for Acute DIC

6. Miscellaneous Questions

Bleeding Time Versus PFA-100
Cocaine and DDAVP
Hyponatremia and DDAVP
The Use of the INR
Selective Serotonin Reuptake Inhibitors and Clotting Disturbances
Work-up for Children with Intracranial Bleeding

7. Thrombotic Disorders

Are Asians genetically different from Westerners when it comes to VTE?
Treatment of Antithrombin Deficiency
Anticardiolipin Antibody Questions
Pediatric Antiphospholipid Syndrome and Recurrent Thrombosis
Anticoagulation for Deep Venous Thrombosis in the Presence of an Intracranial Hemorrhage
Clinical Probability Assessment for Thromboembolic Disease
D-dimer in Thromboembolic Disease
Progestins and Thrombosis
Unknown Thrombophilia and Surgery

Hematology is a particularly visual science. It has always been possible to look at blood cells and their progenitors in the bone marrow with comparative ease. Of all the areas of medicine, Hematology is perhaps the one most amenable to presentation in an Atlas such as this. The Atlas of Clinical Hematology describes the exciting advances occurring in Hematology and presents them in an attractive and useable way.

The Atlas of Clinical Hematology describes the exciting advances occurring in hematology and presents them in an attractive and accessible format.

Contents:

• Non-Hodgkin Lymphoma
• Hodgkin Lymphoma and Other Distinctive Lymphoid Proliferations
• Plasma Cell Disorders
• Myeloid Disorders
• Disorders of Hemostasis and ThrombosisAnemias
• Hematopoietic Stem Cells and Cytokines

Blood Cells: A Practical Guide 4E by Barbara J. Bain Hardcover - 488 pages Shipped in CLICK HERE Cat.# JW-HEM4 $174.55 BUY Published:  2006   ISBN:  9781405142656

Blood Cells has been written with both the practising haematologist and the trainee in mind. It aims to provide a guide for use in the diagnostic haematology laboratory, covering methods of collection of blood specimens, blood film preparation and staining, the principles of manual and automated blood counts and the assessment of the morphological features of blood cells. The practising haematologist should find this book sufficiently comprehensive to be a reference source while, at the same time, the trainee haematologist and biomedical scientist should find it a straightforward and practical bench manual.

Enables both the haematologist and laboratory scientist to identify blood cell features, from the most common to the more obscure

• Provides essential information on methods of collection, blood film preparation and staining, together with the principles of manual and automated blood counts
• Completely revised and updated, incorporating much newly published information: now includes advice on further tests when a specific diagnosis is suspected
• Four hundred high quality photographs to aid with blood cell identification
• Highlights the purpose and clinical relevance of haematology laboratory tests throughout

Table of Contents:

1 Blood Sampling and Blood Film Preparation and Examination
2 Performing a Blood Count
3 Morphology of Blood Cells
4 Detecting Erroneous Blood Counts
5 Normal Ranges
6 Quantitative Changes in Blood Cells
7 Important Supplementary Tests
8 Disorders of Red Cells and Platelets
9 Disorders of White Cells

Index

Pediatric Hematology 3E by Robert J. Arceci, Ian M. Hann, Owen P. Smith, and A. Victor Hoffbrand Hardcover - 840 pages Shipped in CLICK HERE Cat.# JW-HEM5 $326.35 BUY Published:  2006   ISBN:  9781405134002

Pediatric Hematology is a comprehensive and succinct referenced text on the diagnosis and treatment of blood diseases in childhood. It provides a ready source of reference for all the conditions likely to be encountered in day-to-day clinical practice. For each condition, the authors give helpful advice on differential diagnoses and clinical management. This third edition has been extensively updated throughout, in light of recent developments in this rapidly advancing area of medicine. A well established textbook on the diagnosis and treatment of blood disorders in childhood.

• A balanced and cutting edge referenced text on all aspects of diagnosis and treatment
• Easy to use, practically organized, with essential aspects of biology included within each chapter
• International editorial and contributor team—representing a wide geographical and chronological range

Whether you are an established sub-specialist in pediatric hematology/oncology, a pediatrician, a trainee or nursing specialist, this book will answer all your questions about benign and malignant disorders of the blood in children and young adults.

Table of Contents:

Section 1: The Scientific Basis

1. Hematopoiesis: an introduction.

Section 2: Marrow Failure Syndromes

2. Failure of red cell production
3. Inherited bone marrow failure syndromes
4. Acquired aplastic anemia

Section 3: Red Cell Disorders

5. Disorders of iron metabolism: iron deficiency, iron overload and the sideroblastic anemias
6. Megaloblastic anemia and disorders of cobalamin and folate metabolism
7. Nonimmune neonatal anemias
8. Immune hemolytic anemias
9. Disorders of erythrocyte metabolism including porphyria
10. Sickle cell disease
11. Hemoglobin variants and the rarer hemoglobin disorders
12. Red cell membrane abnormalities
13. Thalassemias

Section 4: Granulocyte Disorders

14. Disorders of granulopoiesis and granulocyte function
15. Histiocytic disorders
16. Acute myeloid leukemia
17. Chronic myeloid leukemia
18. Myelodysplastic syndromes

Section 5: Lymphocyte Disorders

19. Primary and acquired immunodeficiency
20. Clinical features and therapy of lymphoblastic leukemia
21. Lymphomas

Section 6: Platelet Disorders

22. Inherited and congenital thrombocytopenia
23. Idiopathic thrombocytopenic purpura
24. Thrombocytosis
25. Platelet function disorders

Section 7: Coagulation Disorders

26. Hemophilia A and B
27. von Willebrand disease
28. Rare congenital hemorrhagic disorders
29. Acquired disorders of hemostasis
30. Bleeding in the neonate
31. Thromboembolic complications in children

Section 8: Supportive Therapy

32. Blood components and fractionated plasma products: preparation, indications and administration
33. Hazards of transfusion
34. Management of infection in children with bone marrow failure

Section 9: Secondary Problems

35. Hematologic effects of systemic disease and nonhematopoietic tumors
36. Lysosomal storage disorders
37. Reference values

Index

Postgraduate Haematology 5E by A. Victor Hoffbrand, Daniel Catovsky, and Edward G. D. Tuddenham Hardcover - 1,080 pages Shipped in CLICK HERE Cat.# JW-HEM6 $326.35 BUY Published:  2005   ISBN:  9781405108218

"Most hematologists need a revised and practical textbook in which they can rapidly search on the morning of a consultation...This book will be an important resource in such situations."
New England Journal of Medicine

Postgraduate Haematology is a practical, readable text which will give trainees, residents and practising hematologists up-to-date knowledge of the pathogenesis, clinical and laboratory features and management of blood disorders. Postgraduate Haematology is ideal for:

• Trainees and residents in hematology
• Hematologists in practice

A well established and respected review of hematology.

• Practical and readable text
• Essential information for everyday use as well as the scientific background
• Up-to-date knowledge of the pathogenesis, clinical and laboratory features and management of blood disorders
• Complete revision of all chapters and the addition of new chapters to reflect latest advances in the speciality

Table of Contents:

Contributors
Preface to the fifth edition
Preface to the first edition

1. Stem Cells and Haemopoiesis
2. Erythropoiesis
3. Iron deficiency/ metabolism
4. Iron overload
5. Megaloblastic Anaemia
6. Haemoglobin Defects
7. Sickle Cell Anaemia
8. Red Cell Membrane Disorders
9. Red Cell Metabollic Disorders
10. PNH
11. Acquired HA
12. Acquired Aplastic Anaemia
13. Inherited Aplastic Anaemia
14. Immunohaematology: Introduction
15. Antigens in Human Blood
16. Clinical Blood Transfusion
17. Phagocytic white blood cells and their role in the host defence system
18. Haemopoietic Growth Factors
19. Storage Disorders
20. Lymphocytes
21. Immune Deficiency
22. HIV
23. Tissue Typing
24. Stem Cell Transplantation
25. Non-Myelopablative Transplantation
26. Gene Therapy for Haematological Disorders
27. Molecular Basis of Leukaemia and Lymphoma
28. Classification of Acute Leukaemia
29. Cytogenetics of Acute Leukaemia
30. Clinical and Treatment Aspects of AML
31. Adult AML
32. Childhood AML
33. Minimal Residual Disease in Acute Leukaemia
34. Multi-Drug Resistance in Leukaemia
35. Supportive Care in the Management of Acute Leukaemia
36. Chronic Myeloid Leukaemia
37. Chronic Lymphocytic Leukaemia
38. T-Cell Lymphoproliferative Diseases
39. Myelodysplastic Syndrome
40. Myeloma
41. Amyloidosis
42. Classification of Lymphomas
43. Management of Hodgkin's Disease
44. Management of Non-Hodgkin's Lymphoma
45. Myeloproliferative Disorders
46. Normal Haemostasis
47. Platelets
48. Congenital Bleeding- X linked disorders and Von Willebrand Disease
49. (Rare Bleeding Disorders) Congenital Bleeding- autosomal recessive disorders
50. Acquired Bleeding Disorders
51. Thrombotic Thrombocytopenic Purpura (congenital and acquired) and Haemolytic Uraemic Syndrome
52. Thrombosis- Congenital
53. Venous Thrombosis- Acquired
54. Management of Venous Thrombotic Disorders
55. Congenital Platelet Disorders
56. Acquired Immune Platelet Disorders
57. Athero-thrombosis, Thrombolysis & Antiplatelets
58. Haematological Aspects of Systemic Diseases
59. Haematological Aspects of Tropical Diseases
60. Neonatal Haematology
61. Laboratory Practice

Appendix 1: Normal Values
Appendix 2: WHO Classification of tumours of haemopoietic and lymphoid tissues

Index

Molecular Hematology 2E by Drew Provan, and John Gribben Hardcover - 344 pages Shipped in CLICK HERE Cat.# JW-HEM7 $238.20 BUY Published:  2005   ISBN:  9781405112550

Unique text providing a core knowledge base for those with little exposure
to molecular biological methods

Molecular Haematology provides essential reading for those with minimal exposure to, or understanding of, molecular biological techniques. There is an extensive glossary and each chapter is written with the non-specialist in mind. Molecular Haematology is ideal for:

• Trainees and residents in hematology
• Hematologists in practice

Unique text providing a core knowledge base for those with little exposure to molecular biological methods

• Focuses on the clinical relevance of molecular biology in haematology
• Complete revision of text and ten new chapters to cover all groundbreaking developments in the field
• Each chapter summarizes the impact made by molecular research on understanding the pathogenesis of a variety of blood disorders
• International team of contributors recruited from top specialist units around the world

Table of Contents:

List of Contributors
Foreword
Preface
Abbreviations

1. Beginnings: The Molecular Pathology of Hemoglobin
2. Molecular Cytogenetics
3. Stem Cells
4. The Genetics of Aacute Myeloid Leukemias
5. Secondary Myelodysplasia/acute Myelogenous Leukemia—assessment of Risk
6. Detection of Minimal Residual Disease in Hematological Malignancies
7. Chronic Myeloid Leukaemia
8. Myelodysplastic Syndromes
9. Myeloproliferative Disorders
10. Lymphoid Neoplasms
11. The Molecular Biology of Multiple Myeloma
12. The Molecular Basis of Anaemia
13. The Moloecular Basis of Iron Metabolism
14. Hemoglobinopathies Due to Structural Mutations
15. Molecular Coagulation and Thrombophilia
16. The Molecular Basis of Haemophilia
17. The Moloecular Basis of Von Willebrands Disease
18. Platelet Disorders
19. The Molecular Basis of Blood Cell Alloantigens
20. Functions of Blood Group Antigens
21. Autoimmune Hematological Disorders
22. Hemotopoietic Growth Factors
23. Molecular Therapeutics in Hematology
24. Gene Expression Profiling in the Study of Lymphoid Malignancies

Appendices
Index
Color plate

Textbook of Hemophilia by Christine A. Lee, Erik E. Berntorp, W. Keith Hoots, and Louis M. Aledort Hardcover - 416 pages Shipped in CLICK HERE Cat.# JW-HEM8 $304.55 BUY Published:  2005   ISBN:  9781405127691

The only up-to-date definitive reference source on hemophilia

This book is an invaluable resource that provides an overview of all aspects of the care of patients with haemophilia.

Covering how to assess both bleeding children and adults, Haemophilia A and B, molecular basis of the disease, the role of factors in coagulation, epidemiology, pharmacokinetics, and treatment of inhibitors. There will also be a section on musculoskeletal aspects of haemophilia as well as newer developments such as gene therapy and rare bleeding disorders. Textbook of Hemophilia is ideal for:

• Trainees and residents in hematology
• Hematologists in practice
• Specialists working in thrombosis and hemostasis as well as transfusion medicine

The only up-to-date definitive reference source on hemophilia.

• Essential for all those managing hemophilia patients
• Detailed guidance on assessment, diagnosis, management and treatment
• Advice for everyday clinical questions
• Edited by three of the world’s leading experts on hemophilia

Table of Contents:

Contributors
Foreword

Part I: Introduction

1. Overview of Hemostasis
2. Cellular Processing of Factor VIII and IX
3. Work-up of a Bleeding Adult

Part II: HEMOPHILIA A

4. Molecular Basis of Hemophilia A
5. Hemophilia A: Role of Factor VIII in Coagulation
6. Natural History of Inhibitor Development in Children with Severe Hemophilia A Treated with Factor VIII Products
7. Prophylaxis
8. Continuous Infusion of Coagulation Products in Hemophilia

Part III: Inhibitors to Factor VIII

9. Inhibitors to Factor VIII - Immunology
10. Inhibitors to Factor VIII - Molecular Basis
11. Inhibitors to Factor VIII - Epidemiology and Treatment
12. Inhibitors to Factor VIII - Mid and Moderate Hemophilia
13. Inhibitors to Factor VIII/IX: Treatment of Inhibitors - Immune Tolerance Induction
14. Inhibitors of Factor VIII: Treatment of Acute Bleeds

Part IV: Acquired Hemophilia.

15. Acquired Inhibitors to Factor VIII

Part V: Hemophilia B

16. Hemophilia B - Molecular Basis
17. Inhibitors in Hemophilia B
18. Treatment Inhibitors in Hemophilia B

Part VI: Pharmacokinetics of Factors VIII & IX

19. Pharmacokinetics

Part VII: Pediatrics

20. Work-up of a Bleeding Child
21. Care of the Child with Hemophilia
22. To Neonate with Hemophilia

Part VIII: Products Used to Treat Hemophilia

23. Products Used to Treat Hemophilia: Evolution of Treatment for Hemophilia A and B
24. Products Used to Treat Hemophilia: Recombinant Products
25. Products Used to Treat Hemophilia: Plasma-Derived Coagulation Factor Concentrates
26. Products Used to Treat Hemophilia: Recombinant Factor VIIa
27. Products Used to Treat Hemophilia: Dosing
28. Products Used to Treat Hemophilia: Regulation.

Part IX: Muscoskeletal

29. Joint Replacement
30. Synovioarthesis in Hemophilia
31. Pseudotumours in patients with Hemophilia
32 Radiology
33. Magnetic Resonance Imaging/ Joint Outcome
34. Physiotherapy in the Management of Hemophilia

Part X: Transfusion-Transmitted Disease

35. Transfusion Transmitted Disease: History of Epidemics (Focus on HIV)
36. Transfusion Transmitted Disease: Hepatitis C Virus Infection and Liver Transplantation

Part XI: Gene Therapy

37. Gene Therapy: Introduction and Overview
38. Gene Therapy for Hemophilia B
39. Gene Therapy for Hemophilia A
40. Gene Therapy: Molecular Engineering of Factor VIII and Factor IX

Part XII: Laboratory

41. Laboratory Assays in Hemophilia
42. Standardization of Assays

Part XIII: Obstetrics & Gynaecology

43. Obstetrics and Gynecology: Hemophilia

Part XIV: Von Willebrand Disease

44. von Willebrand Disease: Molecular Aspects
45. von Willebrand Disease: Epidemiology
46. von Willebrand Disease: Biological Diagnosis
47. Classification and Clinical Aspects of von Willebrand Disease

Part XV: Treatment of Von Willebrand Disease

48. Treatment of von Willebrand Disease: Desmopressin
49. Treatment of von Willebrand Disease: Therapeutic Concentrates
50. Women & Von Willebrand Disease

Part XVI: Rare Bleeding Disorders

51. Factor II
52. Factor V and combined Factor V and VIII Deficiencies
53. Congenital Factor VII Deficiency
54. Factor X and Factor X Deficiency
55. Factor XI Deficiency
56. Factor XIII
57. Fibrinogen
58. Miscellaneous Rare Bleeding Disorders

Part XVII: Quality of Life

59. Quality of Life in Hemophilia

Part XVIII: Economics

60. The Economics of Hemophilia Treatments

Part XIX: Comprehensive Care and Delivery of Care.

61. Comprehensive Care and Delivery of Care: The Developed World
62. The Comprehensive Care and Delivery of Care: The Developing World
63. Comprehensive Care and Delivery of Care: The Global Perspective

Index

Clinical Hematology by Neal Young, Stanton Gerson, and Katherine High Hardcover - 1,456 pages Shipped in CLICK HERE Cat.# EL-HEM3 $264.55 BUY Published:  2005   ISBN:  9780323019088

Written by a young, innovative author group, this exciting new book gives you the clinically relevant aspects of hematology in an innovative, unique format. The book is structured to comprehensively cover the complete scope of hematology, but allows fast access to key information you need in everyday practice. A section on consultative hematology includes chapters on special populations (pregnancy, pediatrics, geriatrics), infections of marrow and blood, and hematologic problems of medical practice and surgery. You'll also find a section on tools for the hematologist, covering clinical aspects of transfusion, transplantation, and the latest innovative laboratory procedures.

• Provides critical information relevant to everyday practice, reflecting the way hematology is practiced today.
• Covers basic science only as it relates to clinical practice.
• Utilizes full-color photographs, illustrations, and functional drawings to highlight critical information and difficult concepts.
• Uses consistent, templated chapters to make essential information uncommonly easy to find.
• Offers a unique approach by innovative experts in the field.
• Includes a CD-ROM containing all of the book's figures, tables, algorithms, and charts all downloadable for PowerPoint® presentations, as well as a comprehensive reference library.

Table of Contents:

I. Basic Science of Hematology

1. Hematopoiesis (including cytokines)
2. Globin/Heme
3. Erythrocyte structure
4. Red cell antigens
5. Granulocyte biology
6. Lymphocyte biology (including Ig)
7. Megakaryocytes and platelets
8. Coagulation factors
9. Vascular biology

II. Hematologic Diseases

Section 1. Diseases of Hematopoietic Cell Production
1. Marrow failure
2. Acquired aplastic anemia
3. Fanconi anemia and dyskeratosis congenital
4. Pure red cell aplasia
5. Myelodysplastic syndromes
6. Hairy cell leukemia
7. Large granular lymphocytic leukemia
8. Mineral and vitamin deficiencies
9. Iron deficiency
10. Pernicious anemia and folate deficiency
11. Anemia of chronic disease

Section 2. Diseases of Blood Cell Destruction
1. Hemolytic anemias
2. Inherited HA
3. Sickle cell disease and other hemoglobinopathies
4. Thalassemias
5. Hereditary spherocytosis
6. RBC enzymopathies
7. Acquired HA
8. Autoimmune HA
9. Paroxysmal nocturnal hemoglobinuria
10. Mechanical HA
11. Immune thrombocytopenias
12. ITP, PTP, neonatal TP
13. Drug-induced thrombocytopenia
14. Heparin-induced thrombocytopenia
15. TTP and HUS
16. Neutropenias
17. Kostmann's and other onstitutional neutropenias
18. Agranulocytosis, pure white cell aplasia

Section 3. Malignant and Proliferative Hematologic Diseases
1. Leukemias
2. Leukemias: diagnosis and classifications
3. Acute myelogenous leukemia
4. Secondary MDS/AML
5. Chronic myelogenous and myelomonocytic leukemia
6. Acute lymphocytic leukemia
7. Pediatric leukemias
8. Chronic lymphocytic leukemia
9. Myeloproliferative diseases
10. Polycythemia vera and essential thrombocytosis
11. Myelofibrosis
12. Hypereosinophilia
13. Lymphomas and lymphoid malignancies
14. Biology of lymphoid malignancy
15. Hodgkins disease
16. Cutaneous lymphomas
17. CNS lymphomas
18. NonHodgkins lymphomas
19. Infectious malignancies
20. HIV-1 and HTLV-1-associated lymphomas
21. EBV, HHV-8
22. Cryoglobulinemia
23. Multiple myeloma
24. MGUS
25. Macroglobulinemia
26. Histiocytosis
27. Amyloidosis
28. Mastocytosis
29. Diseases of the spleen

Section 4. Inherited and Acquired Metabolic Blood Diseases
1. Porphyrias
2. Hemochromatosis
3. Familial Mediterranean fever
4. ALPS

Section 5. Diseases of Altered Coagulation Bleeding Disorders
1. Platelet diseases
2. Inherited and acquired platelet disorders
3. von Willebrands disease
4. Coagulation factor disorders
5. Hemophilias (F VIII and IX deficiencies)
6. Acquired inhibitors
7. Thrombotic disorders
8. Inherited deficiencies of proteins C, S; factor V
9. Leiden
10. Anti-phospholipid syndrome
11. Heparin-induced thrombocytopenia

III. Consultative Hematology

Section 1. Hematology of Growth, Development, and Aging
1. Hematologic complications of pregnancy
2. Hematology of the newborn
3. Pediatric hematology
4. Geriatric hematology

Section 2. Infections of Marrow and Blood Viruses
1. Epstein-Barr virus
2. CMV
3. HHV-8 and other herpesviruses
4. Parvovirus B19
5. HIV-1 and the hematology of AIDS
6. Hepatitis C
7. Dengue and hemorrhagic fever viruses
8. Protozoa
9. Malaria
10. Bartonellosis and others
11. Parasites
12. Hookworm

Section 3. Hematologic Problems of Medical Practice Anemia
1. Hematologic drug reactions
2. Erythrocytosis
3. Kidney disease
4. Liver disease
5. Chronic bruising and the bleeding diathesis evaluation
6. Venous and arterial thrombosis
7. Anticoagulant therapy
8. Disseminated intravascular coagulation
9. Chemotherapy toxicities and complications

Section 4. Hematologic Complications in Surgery
1. Evaluation of the acutely bleeding patient
2. Surgery in specific hematologic conditions

IV. Tools for the Hematologist

Section 1. Specialized practice
1. HLA and Transplantation of Unrelated Cells
2. Marrow and blood transplantation
3. Supportive care during transplantation
4. Graft-versus-host disease
5. Transfusion medicine
6. Practice of blood component transfusion
7. Complications of transfusion (incl hepatitis, 2o iron overload)

Section 2. Laboratory Methods
1. Blood and marrow morphology (incl histochemistry)
2. Flow cytometry
3. Cytogenetics/FISH
4. DNA/functional genomics
5. Coagulation Testing

Often referred to as "the bible of hematology," this highly successful, practical manual is the place to turn to for every aspect of laboratory hematology. The book covers all of the techniques used in the investigation of patients with blood disorders, including the latest technologies as well as the tried-and-true manual methods of measurement. It comprehensively discusses which test to use for each situation, the principles of each test, possible causes of error, and the interpretation and clinical significance of the findings. Each chapter conforms to a template, providing quick, easy access to key information. Extensive updates throughout bring you expert guidance on advancing technologies as well as contemporary laboratory organization and management, while retaining the strengths that have made this book an essential reference on laboratory hematology for over 50 years.

• Contains crucial instructions for performing and interpreting lab tests in any sized laboratory.
• Provides complete coverage of all levels of diagnostic testing from the basic to the most advanced.
• Uses helpful decision trees to make the critical information you need easy to locate and understand.
• Features state-of-the-art information on the hottest areas of the field, including Diagnostic
• Radionuclides in Hematology and Molecular and Cytogenetic Techniques.
• Demonstrates important lab findings with over 300 illustrations and color photographs.

Table of Contents:

1. Collection and Handling of Blood
2. Reference Ranges and Normal Values
3. Basic Haematological Techniques
4. Preparation and Staining Methods for Blood and Bone Marrow Films
5. Blood Cell Morphology in Health and Disease
6. Bone Marrow Biopsy
7. Iron Deficiency Anaemia and Iron Overload
8. Investigation of Megaloblastic Anaemia – Cobalamin, Folate, and Metabolite Status
9. Laboratory Methods Used in the Investigation of the Haemolytic Anaemias
10. Investigation of the Hereditary Haemolytic Anaemias: Membrane and Enzyme Abnormalities 11. Acquired Haemolytic Anaemias
12. Investigation of Abnormal Haemoglobins and Thalassaemia
13. Erythrocyte and Leucocyte Cytochemistry
14. Immunophenotyping
15. Diagnostic Radioisotopes in Haematology
16. Investigation of Haemostasis
17. Investigation of a Thrombotic Tendency
18. Laboratory Control of Anticoagulant, Thrombolytic and Antiplatelet Therapy
19. Blood Cell Antigens and Antibodies: Erythrocytes, Platelets and Granulocytes
20. Laboratory Aspects of Blood Transfusion
21. Molecular and Cytogenetic Analysis
22. Miscellaneous Tests
23. Approach to the Diagnosis and Classification of Blood Diseases
24. Laboratory Organization and Management
25. Laboratory Safety
26. Quality Assurance
27. Haematology in Under-Resourced Laboratories
28. Appendices

Hematology by Ronald Hoffman, Edward Benz, Sanford Shattil, Bruce Furie, Harvey Cohen, Leslie Silberstein, & Philip McGlave Hardcover - 2,864 pages Shipped in CLICK HERE Cat.# EL-HEM5 $373.65 BUY Published:  2004   ISBN:  9780443066283

The fourth edition of this leading text reflects the new direction and growth of the field of hematology as an academic and clinical discipline. Edited and written by practitioners who are the leaders of the field, the book covers both the basic scientific foundations of hematology and its clinical aspects. It provides practitioners with the most comprehensive, authoritative, up-to-date information in hematology. The table of contents has been thoroughly revised with many new chapters added, reflecting the rapidly changing nature of the molecular and cellular areas of the specialty. This definitive resource is the one comprehensive book needed by every practicing hematologist.

• Full color throughout for the first time (color figures in place!)
  E-dition available
• The definitive, complete reference resource for hematologic disorders provides "one-stop shopping" for information; appeals to both practitioners and researchers
• Red "opinion" boxes contain treatment strategies and recommendations by the experts
• Only text to include a section on transplantation
• Clinically oriented focus
• Includes more than 15 new chapters

Table of Contents:

Part I. MOLECULAR AND CELLULAR BASIS OF HEMATOLOGY
Chapter 1 Anatomy and Physiology of the Gene
Chapter 2 Genomic Approaches to the Study of Hematologic Science
Chapter 3 Protein Synthesis, Processing, and Degradation
Chapter 4 Protein Architecture: Relationship of Form and Function
Chapter 5 Regulation of Cellular Response
Chapter 6 Cell Adhesion
Chapter 7 Control of Cell Division
Chapter 8 Cell Death
Chapter 9 Pharmacogenomics and Hematological Diseases

Part II. IMMUNOLOGIC BASIS OF HEMATOLOGY
Chapter 10 Overview and Compartmentalization of the Immune System
Chapter 11 B-Cell Development
Chapter 12 T-Cell and NK-Cell Immunity
Chapter 13 Dendritic Cell Biology
Chapter 14 Regulation of Activation of B and I Lymphocytes
Chapter 15 Leukocyte Trafficking
Chapter 16 Tolerance and Autoimmunity

Part III. BIOLOGY OF STEM CELLS AND DISORDERS OF HEMATOPOIESIS
Chapter 17 Stem Cell Model of Hematopoiesis
Chapter 18 Bone Marrow Microenvironment
Chapter 19 The Humeral Regulation of Hematopoiesis
Chapter 20 Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
Chapter 21 Granulopoiesis and Monocytopoiesis
Chapter 22 Thrombocytopoiesis
Chapter 23 Thrombocytopenia Due to Decreased Platelet Production
Chapter 24 Inherited Forms of Bone Marrow Failure
Chapter 25 Aplastic Anemia
Chapter 26 Paroxysmal Nocturnal Hemoglobinuria
Chapter 27 Pure Red Cell Aplasia

Part IV. RED BLOOD CELLS
Chapter 28 Pathobiology of the Human Erythrocyte and Its Hemoglobins
Chapter 29 Approach to Anemia in the Adult and Child
Chapter 30 Anemia of Chronic Diseases
Chapter 31 Pathology of Iron Metabolism
Chapter 32 Disorders of Iron Metabolism : Iron Deficiency and Overload Gary
Chapter 33 Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
Chapter 34 Megablastic Anemias
Chapter 35 Thalassemia Syndromes
Chapter 36 Pathology of Sickle Cell Disease
Chapter 37 Sickle Cell Disease
Chapter 38 Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias
Chapter 39 Red Cell Enzymopathies
Chapter 40 Red Cell Membrane Disorders
Chapter 41 Autoimmune Hemolytic Anemias
Chapter 42 Extrinsic Nonimmune Hemolytic Anemias

Part V. HOST DEFENSE AND ITS DISORDERS
Chapter 43 Complement Biology and Immunoglobulin
Chapter 44 Normal Phagocyte Structure and Function
Chapter 45 Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes
Chapter 46 Disorders of Phagocyte Function and Number
Chapter 47 Disorders of Lymphocyte Function
Chapter 48 Histiocytic Disorders
Chapter 49 Lysosomal Storage Diseases: Perspective and Principles
Chapter 50 Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases
Chapter 51 The Spleen and Its Disorders
Chapter 52 Basophils, Mast Cells, and Systemic Mastocytosis

Part VI. HEMATOLOGIC MALIGNANCIES
Chapter 53 Conventional Cytogenetics and Molecular Cytogenetics in Hematological Malignancies Chapter 54 The Molecular Basis of Neoplasia
Chapter 55 Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies
Chapter 56 Radiation Therapy in the Treatment of Hematologic Malignancies
Chapter 57 Clinical Use of Hematopoietic Growth Factors
Chapter 58 Radioimmunotherapy for B-Cell and Non-Hodgkin Lymphoma
Chapter 59 Pathobiology of Acute Myeloid Leukemia
Chapter 60 Clinical Manifestations of Acute Myeloid Leukemia
Chapter 61 Therapy for Acute Myeloid Leukemia
Chapter 62 Acute Myeloid Leukemia in Children
Chapter 63 Pathobiology of Acute Lymphoblastic Leukemia
Chapter 64 Clinical Manifestations of Acute Lymphoblastic Leukemia
Chapter 65 Treatment of Childhood Acute Lymphoblastic Leukemia
Chapter 66 Acute Lymphoblastic Leukemia in Adults
Chapter 67 Myelodysplastic Syndrome: Biology and Treatment
Chapter 68 Polycythemia Vera
Chapter 69 Chronic Myeloid Leukemia
Chapter 70 Myelofibrosis with Myeloid Metaplasia
Chapter 71 Essential Thrombocythemia
Chapter 72 Myelodysplastic Syndromes and Myeloproliferative Syndromes in Children
Chapter 73 Pathobiology of Non-Hodgkin Lymphomas
Chapter 74 Patho-Biology of Hodgkin’s Lymphoma
Chapter 75 Hodgkin’s Disease: Clinical Manifestations, Staging, and Therapy
Chapter 76 The Pathologic Basis for the Classification of Non-Hodgkin Lymphomas
Chapter 77 Clinical Manifestations, Staging, and Treatment of Non-Hodgkin Lymphoma
Chapter 78 Malignant Lymphomas in Childhood
Chapter 79 Chronic Lymphocytic Leukemia
Chapter 80 Hairy Cell Leukemia
Chapter 81 Cutaneous T-Cell Lymphomas
Chapter 82 AIDS-Related Lymphomas
Chapter 83 Multiple Myeloma and Other Plasma Cell Disorders
Chapter 84 Immunoglobulin Light Chain Amyloidosis (Primary Amyloidosis, AL)
Chapter 85 Atypical Immune Lymphoproliferations
Chapter 86 Clinical Approaches to Infections in the Compromised Host
Chapter 87 Nutritional Support of Patients with Hematologic Malignancies
Chapter 88 Psychosocial Aspects of Hematologic Disorders
Chapter 89 Pain Management and Antiemetic Therapy in Hematologic Disorders
Chapter 90 Palliative Care
Chapter 91 Indwelling Access Devices
Chapter 92 Late Complications of Hematologic Diseases and Their Therapies

Part VII. TRANSPLANTATION
Chapter 93 Hematopoietic Stem Cell Transplantation for Acquired Nonmalignant Diseases and Myelodysplastic Syndrome
Chapter 94 Hematopoietic Cell Transplant for Immune Deficiences and Genetic Diseases
Chapter 95 Results of Allogeneic Hematopoietic Cell Transplant for Hematologic Malignancies
Chapter 96 Autologous Transplant for Hematologic malignancies and Solio Tumors
Chapter 97 Unrelated Donor Stem Cell Transplantation Therapy
Chapter 98 Umbilical Cord Blood Transplantation
Chapter 99 Preparative Regimens for Hematopoietic Cell Transplantation
Chapter 100 Graft-versus-Host Disease and Graft-versus-Leukemia
Chapter 101 Graft Engineering to Enhance Engraftment, Reduce Graft-versus-Host Disease and Provide a Graft-versus-Tumor Effect
Chapter 102 Gene Transfer for Hematologic Disorders
Chapter 103 Experimental Cell Therapy
Chapter 104 Complications After Hematopoietic Cell Transplantation

Part VIII. HEMOSTASIS AND THROMBOSIS
Chapter 105 Megakaryocyte and Platelet Structure
Chapter 106 The Molecular Basis for Platelet Function
Chapter 107 The Molecular Basis for Platelet Activation
Chapter 108 The Blood Vessel Wall
Chapter 109 Molecular Basis of Blood Coagulation
Chapter 110 Molecular and Cellular Basis of Fibrinolysis
Chapter 111 Regulatory Mechanisms in Hemostasis: Natural Anticoagulants
Chapter 112 Clinical Evaluation of Hemorrhagic Disorders: Bleeding History and Differential Diagnosis of Pupura
Chapter 113 Laboratory Evaluation of Hemostatic Disorders
Chapter 114 Structure, Biology, and Genetics of Factor VIII
Chapter 115 Biochemistry of Factor IX and Molecular Biology of Hemophilia B S.
Chapter 116 Clinical Aspects and Therapy of Hemophilia
Chapter 117 Inhibitors in Hemophilia
Chapter 118 Other Clotting Factor Deficiencies
Chapter 119 Disorders of Fibrinogen
Chapter 120 Structure, Biology, and Genetics of von Willebrand Factor
Chapter 121 von Willebrand Disease: Clinical Aspects and Therapy
Chapter 122 Vitamin K: Metabolism and Disorders
Chapter 123 Inhibitors of Blood Coagulation
Chapter 124 Disseminated Intravascular Coagulation
Chapter 125 Hemostatic Defects Associated with Dysproteinemias
Chapter 126 Disorders of Coagulation in the Neonate
Chapter 127 Hypercoagulable States
Chapter 128 Venous Thromboembolism
Chapter 129 Arterial Thromboembolism
Chapter 130 Anticoagulation and Thrombolytic Therapy
Chapter 131 Immune Thrombocytopenic Purpura, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura
Chapter 132 Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome
Chapter 133 Thrombocytopenia Due to Platelet Destruction and Hypersplenism
Chapter 134 Hereditary Disorders of Platelet Function
Chapter 135 Acquired Disorders of Platelet Function

Part IX. TRANSFUSION MEDICINE
Chapter 136 Human Blood Group Anitgens and Antibodies Part 1: Carbohydrate Determinants Part 2: Protein Determinants
Chapter 137 Human Platelet Antigens
Chapter 138 Human Leukocyte Antigen (HLA) and Human Neutrophil Antigen (HNA) Systems
Chapter 139 Principles of Red Blood Cell Transfusion
Chapter 140 Principles of Platelet Transfusion Therapy
Chapter 141 Principles of Neutrophil (Granulocyte) Transfusions
Chapter 142 Transfusion of Plasma Derivatives: Fresh-Frozen Plasma, Cryoprecipitate, Albumin, and Immunoglobulins
Chapter 143 Preparation of Plasma-Derived and Recombinant Human Plasma Proteins
Chapter 144 Transfusion Therapy for Coagulation factor Deficiencies
Chapter 145 Hemapheresis and Cellular Therapy
Chapter 146 Practical Aspects of Stem Cell Collection
Chapter 147 Transfusion Reactions
Chapter 148 Transfusion-Transmitted Diseases
Chapter 149 Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation
Chapter 150 Red Blood Cell Substitutes

Part X. CONSULTATIVE HEMATOLOGY
Chapter 151 Hematologic Manifestations of Systemic Disease: Liver and Renal Disease
Chapter 152 Hematologic Manifestations of Systemic Disease: Infection, Chronic Inflammation, and Cancer
Chapter 153 Hematologic Manifestations of AIDS
Chapter 154 Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis
Chapter 155 Hematologic Aspects of Pregnancy
Chapter 156 Hematologic Manifestations of Childhood Illness

Part XI. SPECIAL TESTS AND PROCEDURES
Chapter 157 Bone Marrow Examination
Chapter 158 Automated Analysis of Blood Cells
Chapter 159 Laboratory Detection of Hemoglobinopathies and Thalassemias
Chapter 160 Antenatal Diagnosis of Hematologic Disorders
Chapter 161 Use of Molecular Techniques in the Analysis of Hematologic Diseases
Chapter 162 Molecular Imaging in Hematology
Appendix Normal Blood Values: Selected Reference Values for Neonatal, Pediatric, and Adult Populations