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Complementary Therapies and the Management of Diabetes and Vascular Disease: A Matter of Balance by Trish Dunning Softcover - 420 pages Shipped in CLICK HERE Cat.# JW-END3 $135.45 BUY Published:  2006   ISBN:  9780470014585

This book brings together important information about complementary therapies and how they are used in diabetes care. It addresses the benefits and risks of complementary therapies and takes an evidence-based approach. Complementary Therapies and the Management of Diabetes and Vascular Disease: A Matter of Balance provides health professionals with appropriate information about complementary therapies so they can discuss these therapies with their patients and help them make informed decisions about their diabetes care.

Managing diabetes depends on achieving life balance, not just metabolic control. This is the first book devoted exclusively to complementary therapies and diabetes, and it has several key features:

• It is an informative evidence-based text that will help health professionals understand complementary therapies commonly used by people with diabetes, their potential benefits, possible adverse events and how these could be minimised or prevented.
• It describes clinical practice guidelines for the safe combination of complementary and conventional therapies in diabetes management.
• It suggests appropriate advice to give people with diabetes and vascular disease about complementary therapies.

Written by experts in the various fields, this book makes important reading for all health professionals managing patients with diabetes and associated vascular disease, including nurses, doctors, dietitians and podiatrists.

Table of Contents:

Preface
Foreword
List of Contributors
Acknowledgements

1. Introduction to Diabetes

1.1 Incidence and prevalence of diabetes
1.2 Overview of diabetes
1.3 Management strategies
1.4 Management targets and regimens
1.5 Short-term complications
1.6 Long-term complications
1.7 Psychological aspects
1.8 Diabetes management requires integrated approaches
1.9 People with diabetes’ needs, capacities and resources
1.10 Health professionals’ needs
1.11 Integration—is it possible?
1.12 Complementary therapies
1.13 Summary

References

2. Complementary Therapy Use

2.1 Introduction
2.2 Defining complementary therapies
2.3 What is traditional use?
2.4 Philosophical basis of CAM
2.5 Frequency of CAM use
2.6 Profile of likely CAM users
2.7 Culture, health beliefs and CAM
2.8 Reported adverse events associated with CAM
2.9 Summary

References

3. Complementary Medicine and Safety

3.1 Introduction
3.2 Practices
3.3 Risks and safety
3.4 Adverse events
3.5 Intrinsic and extrinsic factors
3.6 Pre-market safety mechanisms
3.7 Preventing adverse medicine reactions
3.8 Safety of CM and diabetes management

References

4. Integrating Complementary and Conventional Therapies

4.1 Introduction
4.2 What is integration?
4.3 Concerns about integration
4.4 Benefits of integration
4.5 Obstacles to integration
4.6 How can integration be achieved?
4.7 Current integrative models
4.8 Regulatory issues
4.9 Responsibilities of individual conventional practitioners using complementary therapies
4.10 Evidence-based care and clinical practice guidelines
4.11 Guidelines for patients using complementary therapies
4.12 Quality use of medicines
4.13 Documentation and communication
4.14 Adverse event reporting

References

5. Nutritional Therapies

5.1 Introduction
5.2 Nutritional medicine (NM)
5.3 Nutritional medicine assessment approaches
5.4 The Zone diet
5.5 Total wellbeing diet
5.6 Ketogenic or Atkins diet
5.7 Metabolic typing and ABO blood type diets.
5.8 ABO blood type diet
5.9 The USDA food guide pyramid
5.10 Detoxification diets
5.11 Nutritional supplementation
5.12 Vitamins
5.13 Minerals
5.14 Trace elements
5.15 Essential fatty acids; gamma-linolenic acid and omega 3 fish oils
5.16 Other key nutrients
5.17 Safe use of supplements

References

6. Essential Oils (Aromatherapy)

6.1 Introduction
6.2 Aromatherapy care models
6.3 Essential oils
6.4 Essential oils and diabetes education and management
6.5 Precautions to consider when assessing the suitability of essential oils in patients with renal disease
6.6 Essential oil use
6.7 Mental health and psychological care
6.8 Essential oil application/administration methods
6.9 Essential oil safety issues
6.10 Essential oil – conventional medicine interactions

References

7. Counselling and Relaxation Therapies

7.1 Introduction
7.2 The body and the mind
7.3 Diabetes and the psyche
7.4 Overview of general concepts and approaches
7.5 Stress management techniques
7.6 Summary

References

8. Energy Therapies

8.1 Introduction
8.2 Brief history of energy field medicine within a western context
8.3 Effects of geomagnetic earth rhythms on health and wellness
8.4 Electromagnetic and subtle energy within living organisms
8.5 Effects of subtle and electromagnetic energy on body structure and function
8.6 Brief overview of eastern perspectives of energy healing
8.7 Energy medicine in health care and relevance to diabetes and vascular disease
8.8 Bioenergetic therapies
8.9 Homeopathy
8.10 Summary

References

9. Herbal Medicines and Interactions with Conventional Medicines Used to Manage Diabetes

9.1 Introduction
9.2 Differences between herbal and conventional medicines
9.3 Similarities between herbal medicines and conventional medicines
9.4 Herbal medicines and diabetes
9.5 Herbal medicines and vascular disease
9.6 Herbal interactions
9.7 Pharmacokinetic interactions.
9.8 Pharmacodynamic interactions
9.9 Using herbal medicines in practice and avoiding adverse herb–medicine interactions

References

10. Ayurvedic Management of Diabetes

10.1 Introduction
10.2 Ayurveda
10.3 Ayurvedic diagnosis
10.4 Principles of preparing Ayurvedic herbal medicines
10.5 Maintaining good health
10.6 Ayurveda and diabetes
10.7 Research studies on Ayurvedic herbal remedies
10.8 The evidence base for Ayurvedic medicines
10.9 Adverse effects of Ayurveda

References

11. Chinese Medicine Treatment of Diabetes

11.1 Introduction
11.2 What is Chinese medicine?
11.3 Key theories that guide Chinese medicine practice
11.4 Diagnostic methods
11.5 Chinese herbal medicine
11.6 Acupuncture and moxibustion
11.7 How is diabetes understood in Chinese medicine?
11.8 Chinese herbal medicine in the treatment of diabetes
11.9 Treating diabetes with acupuncture and moxibustion
11.10 Summary

References

12. Australian Aboriginal Traditional Healing Practices

12.1 Introduction
12.2 Aboriginal concepts of health and illness
12.3 Traditional healing practices
12.4 Traditional healing practices as complementary medicine
12.5 Summary

References

13. Massage and Reflexology

13.1 Introduction
13.2 Massage diagnosis and care processes
13.3 Massage and diabetes
13.4 Massage and cardiovascular disease
13.5 Reflexology

References

14. Naturopathy

14.1 Introduction
14.2 The naturopathic consultation
14.3 General management aims
14.4 Naturopathic management options

References

15. Complementary Approaches to Managing Pain

15.1 Introduction
15.2 What is pain?
15.3 Pathophysiology of pain
15.4 Measuring pain severity
15.5 Managing pain
15.6 Common types of pain associated with diabetes
15.7 Summary

References

16. Manipulative Therapies

16.1 The origins of chiropractic therapy
16.2 Osteopathic beginnings
16.3 Relationship among chiropractors, osteopaths and the medical profession
16.4 Principles of manipulative therapies
16.5 Indications for manipulation
16.6 Potential benefits of spinal manipulation
16.7 Risks and complications associated with manipulative therapies
16.8 Summary

References.
Index

Exercise and Sport in Diabetes (Ed.2) by Dinesh Nagi Hardcover - 236 pages Shipped in CLICK HERE Cat.# JW-END4 $131.80 BUY Published:  2006   ISBN:  9780470022061

The new edition of this acclaimed title provides a practical guide to the risks and benefits of undertaking sport and general exercise for patients with diabetes.

Fully updated to reflect the progress and understanding in the field, the book features new chapters and material on insulin pump therapy and exercise, physical activity and prevention of type 2 diabetes, dietary advice for exercise and sport in type 1diabetes, and fluid and electrolyte replacement.

Table of Contents:

Foreword to the First Edition
Preface to the First Edition
Preface to the Second edition

1. Physiological responses to exercise

1.1 Introduction
1.2 Maximal exercise
1.3 Submaximal exercise
1.4 Endurance training
1.5 Muscle fibre composition
1.6 Muscle metabolism during exercise
1.7 Anaerobic and lactate thresholds
1.8 Fatigue and carbohydrate metabolism
1.9 Carbohydrate nutrition and exercise
1.10 Fluid intake before exercise
1.11 Summary

References

2. Exercise in type 1 diabetes

2.1 Introduction
2.2 Exercise physiology
2.3 Insulin absorption
2.4 Hypoglycaemia
2.5 Hyperglycaemia
2.6 Strategy for treatment adjustments
2.7 Evaluation of the intensity and duration of the effort
2.8 Nutritional treatments and adaptations
2.9 Insulin dose adjustment
2.10 Conclusions

References

3. Diet and nutritional strategies during sport and exercise in type 1 diabetes

3.1 What is exercise?
3.2 The athlete with diabetes
3.3 Nutritional principles for optimizing sports performance
3.4 Putting theory into practice
3.5 Identifying nutritional goals
3.6 Energy
3.7 Carbohydrate
3.8 Guidelines for carbohydrate intake before, during and after exercise
3.9 Protein
3.10 Fat
3.11 Vitamins and minerals
3.12 Fluid and hydration
3.13 Pulling it all together

References
Appendices

4. The role of physical activity in the prevention of type 2 diabetes

4.1 Exercise and prevention of type 2 diabetes

References.

5 Exercise, metabolic syndrome and type 2 diabetes (Dinesh K. Nagi).

5.1 Physical activity in type 2 diabetes
5.2 Type 2 diabetes, insulin resistance and the metabolic syndrome
5.3 Effect of exercise on the metabolic syndrome of type 2 diabetes
5.4 What kind of exercise, aerobic or resistance training
5.5 Effects on cardiovascular risk factors
5.6 Regulation of carbohydrate metabolism during exercise in type 2 diabetes
5.7 Effect of physical activity on insulin sensitivity

References

6. The role of exercise in the management of type 2 diabetes

6.1 Introduction
6.2 Benefits of regular physical activity in type 2 diabetes
6.3 Effects on long-term mortality
6.4 Risks of physical activity
6.5 Conclusions

References

7. Exercise in children and adolescents

7.1 Introduction
7.2 Metabolic effects of exercise
7.3 Attitudes to exercise in young adults with type 1 diabetes
7.4 The Firbush camp
7.5 Precautions during exercise
7.6 Summary

References

8 Insuling pump therapy and exercise

8.1 Introduction
8.2 Potential advantages of CSII
8.3 CSII usage
8.4 Benefits of CSII over multiple daily injections
8.5 Potential advantages for CSII use with exercise
8.6 Studies of response to exercise in CSII users
8.7 Practicalities for using CSII with exercise
8.8 Cautions for using CSII with exercise

References

9. Diabetes and the marathon

9.1 Introduction
9.2 Guidelines
9.3 Personal views
9.4 Summary

Bibliography
Useful Addresses

10. Diabetes and specific sports

10.1 General principles
10.2 Canoeing
10.3 Golf
10.4 Hillwalking
10.5 Extreme altitude mountaineering
10.6 Rowing
10.7 Soccer and rugby
10.8 Tennis
10.9 Sub-aqua (scuba) diving
10.10 Skiing
10.11 Restrictions imposed by sports governing bodies
10.12 Conclusions

References

11. Becoming and staying physically active

11.1 Recommendations for physical activity and exercise
11.2 Essential attributes of a physical activity programme for people with diabetes
11.3 Preparation for exercise
11.4 Changing behaviour

References
Appendix 1: Stretching exercises
Appendix 2: Muscular endurance exercises

12 The role of the diabetes team in promoting physical activity

12.1 Introduction
12.2 Educating the diabetes team
12.3 Exercise therapist as part of the team
12.4 Assessment of patients
12.5 The exercise prescription
12.6 Patient education
12.7 Motivating patients and changing behaviour
12.8 Conclusions

References
Inde

The Foot in Diabetes (Ed.4) by Andrew Boulton, Peter Cavanagh, and Gerry Rayman Softcover - 464 pages Shipped in CLICK HERE Cat.# JW-END5 $135.45 BUY Published:  2006   ISBN:  9780470015049

Since the publication of the third edition of The Foot in Diabetes, there have been important developments in the field of diabetic foot care and its scientific basis, including:

• The introduction of new technologies such as vacuum therapy, new casting techniques, the use of hormones and growth factors in wound healing;
• Advances in the understanding of the biomechanics of foot problems;
• Increased problems with multidrug-resistant organisms;
• The introduction of new international guidelines for the management of foot infections;
• Significant progress in the use of cytokines, metalloproteinase inhibitors, stem cells and gene therapy in wound healing.

This fourth edition of this popular title maintains the strengths of earlier editions, with a strong emphasis on practical applications and management. All the chapters have been fully revised and updated, with new chapters introduced to cover the topics listed above. This book features more international contributors, giving it more global relevance than before, and for the first time it includes colour plates.

With its focus on practically oriented advice, this book is essential reading for all members of the diabetes specialist team including diabetologists, podiatrists, specialist nurses, general practitioners, surgeons and clinical researchers.

Table of Contents:

Foreword
Preface
Contributors

1. Epidemiology and Economic Impact of Foot Ulcers
2. The Epidemiology of Amputations and the Influence of Ethnicity
3. Diabetic Neuropathy
4. Microcirculation and Diabetic Foot
5. The Pathway to Ulceration: Aetiopathogenesis
6. What the Practising Clinician Should Know About Foot Biomechanics
7. The Description and Classification of Diabetic Foot Lesions: Systems for Clinical Care, for Research and for Audit
8. Providing a Diabetes Foot Care Service: Lessons from the Veterans Health Affairs in the United States
9. Providing a Diabetic Foot Care Service: The Exeter Integrated Diabetic Foot Project
10. The Diabetic Foot in Primary Care: A UK Perspective
11. Psychological and Behavioural Issues in Diabetic Foot Ulceration
12. Education in the Management of the Foot in Diabetes
13. Infection of the Foot in Persons with Diabetes: Epidemiology, Pathophysiology, Microbiology, Clinical Presentation and Approach to Therapy
14. Challenges in the Infected Diabetic Foot: Osteomyelitis and Methicillin-Resistant Staphylococcus aureus
15. Dressings: Is There an Evidence Base?
16. New and Alternative Treatments for the Diabetic Foot: Stem Cells and Gene Transfer
17. An Introduction to Larval Therapy
18. New and Alternative Treatments for Diabetic Foot Ulcers: Hormones and Growth Factors
19. Radiology and Magnetic Resonance Imaging of the Diabetic Foot
20. Interventional Radiology in the Diabetic Foot
21. Peripheral Vascular Disease and Reconstruction
22. Charcot Foot: What’s New in Pathogenesis and Medical Management?
23. The Operative Treatment of Charcot Neuroarthropathy of the Foot and Ankle
24. Surgery for Ulceration and Infection in the Diabetic Foot
25. Conventional Offloading and Activity Monitoring
26. Amputations in the Diabetic Foot
27. Rehabilitation of the Amputee with Diabetes
28. Footwear for People with Diabetes
29. New Casting Techniques: Introduction to the ‘Instant Total Contact Cast’
30. New Technologies in Wound Healing: Pressure-Relieving Dressings
31. Negative Pressure Wound (VAC) Therapy
32. The Diabetic Foot in Brazil
33. Recent International Developments: India
34. Recent International Developments: Africa
35. The International Consensus on the Diabetic Foot
36. ‘The Organisation of Diabetic Foot Care’: Evidence-Based Recommendations
37. Primary Care: Delivery/Translation of Guidelines into Practice
38. Practical Aspects of Establishing a Multidisciplinary Diabetic Foot Clinic
39. Practical Issues in Diabetes Foot Care: Podiatry – Linking Primary and Secondary Care
40. Algorithms for Assessing Risks for Ulcerations and Amputations

Conclusions
Index

Handbook of Retinal Screening in Diabetes by Roy Taylor Softcover - 188 pages Shipped in CLICK HERE Cat.# JW-END6 $ 49.95 BUY Published:  2006   ISBN:  9780470028827

This book, a successor to the highly popular Practical Guide to Polaroid Retinal Photography, describes the essential components of a retinopathy screening programme, including the criteria for referral to an ophthalmologist, drawing upon the experience of the Newcastle system over the last two decades and the National Screening Committee Report upon Eye screening. It is fully illustrated, featuring a new set of 50 digital colour photographs, showing the normal retina and problems associated with diabetes, with explanatory text.

Table of Contents:

Preface
How to use this book

1. Type 1 Diabetes

What causes type 1 diabetes?
Who gets type 1 diabetes?
How does it present?
Essentials of management
Insulin
Food
Hypoglycaemia
Ketoacidosis
Living with type 1 diabetes
Blood glucose testing
Complications
History
Fact file
Further reading

2. Type 2 Diabetes

What causes type 2 diabetes?
Who gets type 2 diabetes?
How does it present?
Management
Eating
Physical activity
Tablets
Insulin
Living with type 2 diabetes
Blood glucose and urine testing
Complications
History
Further reading
Fact file

3. The Eye in Diabetes

Structure of the normal eye
The retina
Diabetic retinopathy
Other diabetes-associated changes in the eye
Further reading
Fact file

4. The Need to Screen

Is blindness preventable?
Can the progression of retinopathy be slowed?
Detecting asymptomatic retinopathy
The five principles of retinal screening
Quality assurance
History of the development of retinal screening by photography-based systems in the UK
Fact file
Further reading

5. Practical Screening

Important first steps
Measuring visual acuity
Interpretation of visual acuity measurement
Instilling eye drops
Tropicamide
Other eye drops
Obtaining the image
Examining the image
Disc
Vessels
Retina
Explaining the results of screening
Organization of a district screening system
Links with your ophthalmologist
Further reading
Fact file

6. Normal Retinal Appearances

Light reflection artefact (Figure 6.1)
Light reflection artefact (Figure 6.2)
Tortuous vessels (Figure 6.3)
Tiger striping (Figure 6.4)
Tiger striping (Figure 6.5)
Myelinated fibres (Figure 6.6)
Myopic crescent (Figure 6.7)
Pigmented image (Figure 6.8)
Asteroid hyalosis (Figure 6.9)
Choroidal circulation (Figure 6.10)
Eyelash artefact (Figure 6.11)

7. Background Retinopathy

What is background retinopathy?
Lesions
Early background (Figure 7.1)
Early background (Figure 7.2)
Early background (Figure 7.3)
Early background (Figure 7.4)
Early background (Figure 7.5)
Moderate background (Figure 7.6)
8 Severe Non-proliferative (‘Pre-proliferative’) Retinopathy
Severe non-proliferative retinopathy (Figure 8.1)
Severe non-proliferative retinopathy (Figure 8.2)
Severe non-proliferative retinopathy (Figure 8.3)
Severe non-proliferative retinopathy (Figure 8.4)

9. Maculopathy

What is maculopathy?
Management of maculopathy
Blood pressure control
Blood glucose control
Referral to ophthalmologist
Exudates close to the fovea (Figure 9.1)
Severe retinopathy close to the macula (Figure 9.2)
Widespread exudates (Figure 9.3)
Large plaque exudates (Figure 9.4)
Linear exudates close to the fovea (Figure 9.5)
Plaque exudates near the fovea (Figure 9.6)
Circinate exudates within the arcades (Figure 9.7)
Widespread exudates with circinates (Figure 9.8)
Coalescent exudates in the macula region (Figure 9.9)

10. Proliferative Retinopathy

What is proliferative retinopathy?
New vessels on the disc (Figure 10.1)
Disc new vessels (Figure 10.2)
New vessels on the retina (Figure 10.3)
Disc new vessels (Figure 10.4)
New vessels on the retina (Figure 10.5)
New vessels on the retina (Figure 10.6)
Old pan-retinal laser scars (Figure 10.7)
Pan-retinal laser scars (Figure 10.8)

11. Advanced Diabetic Eye Disease

What is advanced?
Early fibrosis (Figure 11.1)
Fibrosis (Figure 11.2)
Fibro-vascular membrane (Figure 11.3)
Pre-retinal haemorrhage (Figure 11.4)
Pre-retinal haemorrhage (Figure 11.5)
Severe exudative maculopathy (Figure 11.6)
Pre-retinal haemorrhage and persisting new vessel formation (Figure 11.7)
Pre-retinal haemorrhages (Figure 11.8)
Fibrous band and heavy laser scars (Figure 11.9)

12. Non-diabetic Eye Disease

What other diseases are common?
Other eye diseases
Glaucoma
Conjunctivitis
Sub-conjunctival haemorrhage
Uveitis
Drusen (Figure 12.1)
Drusen (Figure 12.2)
Atrophic chorioretinital scars (Figure 12.3)
Old chorioretinitis (Figure 12.4)
Papilloedema (Figure 12.5)
One year later – same eye as Figure 12.5 (Figure 12.6)
Papilloedema (Figure 12.7)
Pigment epithelial hypertrophy (Figure 12.8)
Cholesterol embolus (Figure 12.9)
Branch retinal vein occlusion (Figure 12.10)
Branch retinal artery occlusion (Figure 12.11)
Glaucomatous disc (Figure 12.12)
Macular hole (Figure 12.13)

13. Self-assessment Questions

Chapter 1
Chapter 2
Chapter 3
Chapter 4
Chapter 5
Chapters 6–12

14. Background Information

Driving and diabetes
Insurance and diabetes
Employment and diabetes
Prescription charges
British Association of Retinal Screeners (BARS)
Diabetes UK
National Retinopathy Screening Systems
Laser therapy
Vitrectomy
Ophthalmoscopy

15. Answers to Self-assessment Questions

Chapter 1
Chapter 2
Chapter 3
Chapter 4
Chapter 5

16. Glossary of Terms

Index

Staged Diabetes Management (Ed.2) by Roger Mazze, Ellie S. Strock, Richard M. Bergenstal, Gregg D. Simonson Softcover - 456 pages Shipped in CLICK HERE Cat.# JW-END7 $177.25 BUY Published:  2006   ISBN:  9780470061268

Using evidence-based medicine, this title addresses the prominent issues of primary care diabetes management. It provides practical solutions to the detection and treatment of diabetes, its complications and such new areas as metabolic syndrome, pre-diabetes and diabetes in children. The text reviews the fundamental basis of diabetes management and then addresses treatment of each type of diabetes and the major micro- and macrovascular complications.

This Revised Second Edition uniquely focuses on advanced technologies and advanced therapeutics. Key changes include: Integration of incretin hormones in the basic pathophysiology of type 2 diabetes; Incretin mimetics and potentiators; Revised clinical decision paths with new medications and advanced insulin algorithms; New section on continuous glucose monitoring.

Staged Diabetes Management: A Systematic Approach, Second Edition, Revised presents a clear set of clinical algorithms consistent with the EASD/ADA recommended algorithms. It provides a means of applying the principles using a proven methodology and one that has been applied internationally.

• Based on the highly successful diabetes programmes for primary care developed by the the world-renowned International Diabetes Center in Minneapolis, USA
• Features Decision Paths and Practice Guidelines to facilitate clinical decision making
• Clearly written and illustrated: each chapter may be read alone but complements the others to give a broad view of diabetes care

This title is an invaluable guide for healthcare professionals, particularly primary care physicians, diabetes specialist nurses, and for all those with an interest in diabetes. It is also useful for all Diabetes educators and medical students.

Table of Contents:

About the Authors
Acknowledgements

PART ONE STAGED DIABETES MANAGEMENT IN PRACTICE

1. Introduction to Staged Diabetes Management

The development of Staged Diabetes Management
The structure of Staged Diabetes Management
Practice guidelines
Master DecisionPaths
Specific DecisionPaths
Criteria for adjusting and changing therapy
Diabetes Management Assessment DecisionPaths
Metabolic syndrome, complications, and hospitalization DecisionPaths
The patient and Staged Diabetes Management
The diabetes care team
The changing perspective of diabetes care: DCCT and UKPDS
Metabolic syndrome (insulin resistance syndrome)
Children and adolescents with type 2 diabetes and/or metabolic syndrome
Common diagnostic criteria
Diabetes management improvement initiatives
References

2. The Implementation of Staged Diabetes Management

Community diabetes care needs assessment
Group formation
Orientation to Staged Diabetes Management
Customization of Staged Diabetes Management
Evaluation of Staged Diabetes Management
References


3. Therapeutic Principles for the Treatment of Diabetes

Medical nutrition therapy stage
Oral agent stage
Insulin stage
Combination therapies
Evaluating blood glucose control
References

PART TWO THE TREATMENT OF DIABETES

4. Type 2 Diabetes

Etiology
Overview of treatment options for type 2 diabetes
Prevention of type 2 diabetes
Type 2 diabetes detection and treatment
Type 2 Diabetes Practice Guidelines
Type 2 Diabetes Master DecisionPath
New treatment alternatives
Management of acute complications
Type 2 diabetes and pregnancy
Patient education
Behavioral issues and assessment
References

5. Type 2 Diabetes and Metabolic Syndrome in Children and Adolescents

Etiology
Prevention of type 2 diabetes
Major studies
Overview of treatment options for children and adolescents with type 2 diabetes
Obesity and weight management in children and adolescents
Type 2 diabetes in children and adolescents
Metabolic syndrome in children and adolescents
References

6. Type 1 Diabetes

Etiology
Type 1 diabetes detection and treatment
Type 1 diabetes practice guidelines
Screening and Diagnosis DecisionPath
Type 1 Diabetes Master DecisionPath
Management of acute complications
Type 1 diabetes and pregnancy
Patient education
Behavioral issues and assessment
References

7. Pregestational and Gestational Diabetes

Etiology of GDM and hyperglycemia
Adverse fetal and perinatal outcome
Preventing gestational diabetes and subsequent type 2 diabetes
Pregestational diabetes
Gestational diabetes detection and treatment
Gestational diabetes practice guidelines
Gestational Diabetes Master DecisionPath
Pregestational (type 1 and type 2) diabetes treatment options
Fetal and maternal assessment
References

PART THREE INSULIN RESISTANCE AND DIABETES COMPLICATIONS

Overview
Metabolic syndrome (insulin resistance syndrome) and complications
Hospitalization overview

8. Macrovascular Disease

Diabetes and the risk of cardiovascular disease
Role of inflammation in macrovascular disease
Prevention of cardiovascular disease in diabetes: importance of a multifactorial approach
Insulin resistance, hypertension, and cardiovascular disease
Detection and treatment of hyperglycemia, hypertension, and dyslipidemia
Practice guidelines: hypertension and dyslipidemia
Staged management of hypertension
Staged management of hyperlipidemia and dyslipidemia
Additional therapeutic options for prevention and treatment of cardiovascular disease
References

9 Microvascular Complications

Detection and treatment of diabetic nephropathy
Detection and treatment of eye complications
Detection and treatment of diabetic neuropathy
Detection and treatment of foot complications
Detection and treatment of dermatological, connective tissue, and oral complications
Polycystic ovary syndrome (PCOS)
References

10. Hospitalization

The current impact of diabetes related hospitalizations
Hospitalization practice guidelines
Hospitalization for problems related to glycemic control
Hospitalization for illness
Hospitalization for surgery
Reference
Appendix
Index

The Eicosanoids by Peter Curtis-Prior Softcover - 654 pages Shipped in CLICK HERE Cat.# JW-END8 $397.25 BUY Published:  2006   ISBN:  9780471489849

This comprehensive reference work, updated from the first edition, brings together the knowledge and expertise of contributors from around the world. It includes new topics such as prostaglandin synthetase enzyme, new synthetic eicosanoids, innovative analytical methods, the influence of cytokines in the regulation of synthesis and actions, newer eicosanoids that influence the cardiovascular system, and newly discovered roles in reproduction and interactions with nitric oxide.

This book satisfies a surge of interest in prostaglandins - NSAIDS (e.g. aspirin) are the biggest selling drugs of all time, and the field has been refreshed by the advent of new types (selective COX-2 inhibitors, anti-leukotiene drugs).

Table of Contents:

List of Contributors
Preface
Preface from Prostaglandins
Acknowledgements
Foreword

Section One: Biosynthesis and Metabolism

1. Perspectives on the Biosynthesis and Metabolism of Eicosanoids
2. Control of Eicosanoid Production by Cellular and Secreted Phospholipase A2
3. Mechanisms of PGH synthase-1 (COX-1) activity and role of radical states
4. Regulation and Function of Prostaglandin Synthase 2/Cyclooxygenase II
5. Mammalian Lipoxygenases
6. Biosynthesis and Biological Effects of 5-oxo-ETE and other Oxoeicosatetraenoic Acids
7. Synthetic Eicosanoids

Section Two: Analytic al Methods

8. Perspectives of Analytical Methods for Eicosanoids
9. Enzyme Immunoassays of Metabolites and Enzymes Using Acetylcholinesterase as label
10.Bioassay of Eicosanoids
11. Gas Chromatography and Mass Spectometry in Eicosanoid Analysis
12. Time-resolved Fluoroimmunoassay in Eicosanoid Analysis

Section Three: Biochemical and Molecular Pharmacology

13. Perspectives and Clinical Significance of the Biochemical and Molecular Pharmacology of Eicosanoids
14. Eicosanoid Antagonists
15. Biosynthesis and Degredation of Anandamide, an Endogenous Ligand of Cannabinoid Receptors
16. Inhibitors of Eicosanoids
17. Biology and Chemistry of Products of the Isoprostane Pathway
18. Insight into Prostanoid Functions; lessons from receptor-knockout mice

Section Four: Immunology, Endocrinology and Metabolic Regulation

19. Perspectives and Clinical Significance of Eicosanoids in Immunology, Endocrinology and Metabolic Regulation
20. Prostaglandins and the Immune Response
21. Leukotrienes in Aspirin-intolerant Asthma
22. Essential Fatty Acids
23. Endothelial Secretory Function and Atherothrombosis
24. Molecular Regulation of Pancreatic Islet Prostaglandin Sythesis and Its Relevance to Diabetes Mellitus
25. Prostaglandins, Leukotrienes and Bone
26. Aging and Prostaglandins

Section Five: Inflammation

27. Perspectives and Clinical Significance of Eicosanoids in Pain and Inflammation
28. Anti-Inflammatory Steroids
29. Eicosanoids and Algesia in Inflammation
30. Cyclooxygenase-2 in Cancer
31. Cytokines and Eicosanoids in Arthritis

Section Six: Circulatory Systems

32. Prespectives and Clinical Significance of Eicosanoids in the Circulatory System
33. Aspirin and Activated Platelets
34. Generation of Vasoactive Prostanoids by the Cyclooxygenase-2 Pathway in the Cardiovascular System of the Rat
35. Eicosanoid Generation and Effects in Cardiac Muscle and Coronary Vessels

Section Seven: Digestive System

36. Perspective and Clinical Significance of Eicosanoids in the Digestive System
37. Eicosanoids and Liver Regeneration
38. Eicosanoids and the Intestine
39. Eicosanoids and Stomach Physiology

Section Eight: Nervous System

40. Perspectives and Clinical Significance of Arachidonic Acid Release, Action and Metabolism In the Nervous System
41. Eicosanoid Pathways in the Aging of the Central Nervous System
42. Arachidonate Metabolites in the Neurophysiological System: The Fever Pathway
43. Prostanoids in Pain
44. Eicosanoids: Roles in the Pathophysiology of Cerebral Ischemia
45. NSAIDs in the Treatment of Alzheimer’s Disease
46. Prostaglandins and Eicosanoids
47. Essential Fatty Acids: Eicosanoid Precursors in the Treatment of Huntington’s Disease

Section Nine: Conclusions and Correlations

48. Perspectives and Clinical Significance of Eicosanoids in Obstetrics and Gynaecologic Practice
49. Prostaglandins and Male Reproductive Physiology
50. Prostaglandin F2: The Luteolytic Hormone
51. Prostaglandins in Implantation
52. Parturition and the Clinical Interruption of Pregnancy
53. Foetal and Neonatal Ductus Arteriosus

Section Ten: Conclusions and Correlations

54. Biochemical Interactions of Platelet-Activating Factor with Eicosanoids
55. Eicosanoid Precursors as Pharmaceuticals
56. Pharmaceutical Exploitation: cyclooxygenase and lipoxygenase inhibitors
57. Pharmaceutical Exploitation: Eicosanoids and their Analogs

Epilogue
Index

Psychology in Diabetes Care (Ed.2) by Frank J. Snoek, and T. Chas Skinner Softcover - 224 pages Shipped in CLICK HERE Cat.# JW-END9 $135.45 BUY Published:  2005   ISBN:  9780470023846

Psychosocial issues have long been acknowledged to have a crucial role in the successful treatment of people with diabetes. An understanding of these issues can enable health care professionals to assist their patients effectively. The second edition of the acclaimed title Psychology in Diabetes Care gives background information and practical guidelines needed by healthcare professionals to address the cognitive, emotional and behavioural issues surrounding diabetes management.

The book bridges the gap between psychological research on self-care and management of diabetes, and the delivery of care and services provided by the diabetes care team.

Written jointly by psychologists active in diabetes research and practising clinicians, Psychology in Diabetes Care, Second Edition provides a practical evidence-based approach to intervention in diabetes care.

Table of Contents:

List of Contributors
Foreword to the First Edition
Foreword to the Second Edition
Preface to the First Edition
Preface to the Second Edition
List of Contributors

1. Diabetes in Children

1.1 Introduction
1.2 Diabetes in Infancy
1.3 Diabetes in toddlers and preschoolers
1.4 Treatment in issues for children under 6 years of age
1.5 Diabetes in school-aged children
1.6 Family factors related to glycaemic control and adherence
1.7 Family involvement in the diabetes management of a school-aged child
1.8 Treatment issues for school-aged children
1.9 Disease course and risk factors: implications for clinical practice
1.10 Conclusions

References

2. Diabetes in Adolescents

2.1 Introduction
2.2 Familial interventions
2.3 Individual interventions
2.4 Conclusion

References

3. Psychological Issues in the Management of Diabetes and Pregnancy

3.1 Introduction
3.2 Prepregnancy
3.3 Pregnancy
3.4 Delivery
3.5 Lactation
3.6 Childhood
3.7 Practice implications

References

4. References 4 Diabetes in Older Adults

4.1 Introduction
4.2 The ageing process
4.3 Symptoms and their representation
4.4 Clinical features of diabetes
4.5 Diabetes complications in older adults
4.6 Mortality and type 2 diabetes
4.7 Diabetes control and complications
4.8 Quality of life
4.9 Management of diabetes in older adults
4.10 Self-management issues
4.11 Practice implications
4.12 Summary and conclusions

References

5. Patient Empowerment

5.1 Introduction
5.2 Empowerment defined
5.3 Patient empowerment and diabetes
5.4 Implementing the empowerment approach
5.5 Implementing the empowerment approach in diabetes self-management education (DSME)
5.6 Implementing the empowerment approach in diabetes self-management support (DSMS)
5.7 Implementing the empowerment approach in diabetes care
5.8 Costs and benefits of the empowerment approach
5.9 Concluding thoughts

Acknowledgement
References

6. Medical Office-Based Interventions

6.1 Theoretical background
6.2 Clinical and logistic rationale for office-based interventions
6.3 Research findings from office-based interventions
6.4 Target groups for inclusion/exclusion
6.5 Assessment and clinic flow
6.6 Links to medical management
6.7 Unanswered questions, new directions

References

7. Psychological Group Interventions in Diabetes Care

7.1 Psychological group interventions in medical illness
7.2 Psychological group interventions in diabetes
7.3 Psychological group interventions aimed at psychological problems complicating diabetes
7.4 Psychological group interventions dealing with complications of diabetes
7.5 Psychological group interventions dealing with hypoglycaemia
7.6 Groups dealing with the daily demands of diabetes
7.7 Using new technologies for groups
7.8 Discussion and future directions

References

8. Counselling and Psychotherapy in Diabetes Mellitus (Richard R. Rubin).

8.1 Introduction
8.2 Diabetes-related distress
8.3 Psychopathology
8.4 Practice implications

References
Index

Prevention of Type 2 Diabetes by Manfred Ganz Hardcover - 376 pages Shipped in CLICK HERE Cat.# JW-END10 $177.25 BUY Published:  2005   ISBN:  9780470857335

This book provides a unique and comprehensive synopsis of the prevention and early diagnosis of Type 2 Diabetes. It features articles by key opinion leaders in diabetes from North America, Europe and the Asia-Pacific region who describe the gravity of the problem and the important issue of screening, including contributions on the perspectives of the International Diabetes Federation and the World Health Organization.

Once patients at risk have been identified, the key issue is to prevent their progression to full-blown diabetes. Several chapters address this, particularly the difficult task of changing people’s behaviour. Prevention of the complications associated with diabetes involves more targeted interventions, which are discussed by experts in the relevant areas.

This book offers both a global perspective and local solutions. Key contributors include Paul Zimmet and Pierre Lefèbvre, President of the International Diabetes Federation who has written a chapter and a foreword.

Table of Contents:

Foreword
Preface
List of Contributors

SECTION 1: THE DIABETES EPIDEMIC: DESCRIPTION OF THE PROBLEM

1. The Diabetes Epidemic; Genes and Environment Clashing
2. Type 2 Diabetes Mellitus: Primary and Secondary Prevention The Vision of the International Diabetes Federation
3. Type 2 Diabetes Mellitus in Children and Adolescents

SECTION 2: SCREENING FOR TYPE 2 DIABETES

4. Screening for Undiagnosed Diabetes: Whom, Where, When and How
5. Genetic Screening and Prevention of Type 2 Diabetes
6. Screening Parameters and Techniques: Limitations and Opportunities
7. Screening for Diabetes Mellitus – the World Health Organization Perspective

SECTION 3: PREVENTION OF TYPE 2 DIABETES

8. Findings from Preventive Type 2 Diabetes Trials
9. A Paradigm Shift is Needed in the Primary Prevention of Type 2 Diabetes
10. The Behaviour Change Process

SECTION 4: PREVENTION OF COMPLICATIONS OF TYPE 2 DIABETES

11. Preventive Disease Management – Risk Stratification as a New Tool in the Hands of General Practitioners
12. Prevention of Obesity and Lipid Disorders
13. Renal Dysfunction and Hypertension, Focus on Type 2 Diabetes
14. Diabetic Retinopathy in the 21st Century: Screening and Visual Outcomes
15. Prevention and Treatment of Diabetic Neuropathy
16. The Cardiologist’s View: Prevention of Macrovascular Complications
17. Milestones and New Perspectives in Prevention of Type 2 Diabetes and its Complications

Index

Diabetes: Chronic Complications (Ed.2) by Kenneth M. Shaw, and Michael H. Cummings Softcover - 270 pages Shipped in CLICK HERE Cat.# JW-END11 $ 79.05 BUY Published:  2005   ISBN:  9780470865798

Diabetes is one of the leading causes of morbidity and mortality worldwide. Major complications include nephropathy, neuropathy, retinopathy and heart disease, which affect thousands of diabetics every year. The prevention and treatment of such complications encompass pharmacological, surgical and educational approaches, all of which need to be coordinated for optimal management of people with diabetes.

This user-friendly new edition of Diabetes - Chronic Complications (previously called Diabetic Complications) has been completely revised and updated to reflect the rapid developments currently taking place in the field. Each chapter describes the epidemiology, aetiology and management of a particular complication and discusses the organisation and delivery of care.

• Includes all the major chronic complications of diabetes
• Presents a practical approach to the treatment of diabetes complications
• Written by world’s leading experts in the field
• Features algorithms for screening and treatment of diabetes complications

Table of Contents:

Preface to Diabetiic Complications
Foreword to Diabetic Complications
Preface to the Current Edition
List of Contributors

1. Diabetes and the Eye

1.1 Introduction
1.2 Epidemiology of diabetic retinopathy
1.3 Retinal anatomy
1.4 Classification/clinical and histological features of diabetic retinopathy

2. Diabetes and the Kidney

2.1 Introduction
2.2 Normal renal structure and function
2.3 Stages in the development of diabetic renal disease
2.4 Prevalence and significance of microalbuminuria
2.5 Screening for diabetic renal disease
2.6 Initiators and promoters of diabetic renal disease
2.7 Renal morphology and diabetic nephropathy
2.8 Prevention and treatment of diabetic renal disease
2.9 Summary and conclusions

3. Diabetes and Foot Disease

3.1 Introduction
3.2 Diabetic foot ulceration
3.3 Charcot foot
3.4 The organization of foot care
3.5 Conclusion

4. Diabetes and Autonomic Neuropathy

4.1 Introduction
4.2 Causative factors
4.3 Tests of autonomic function
4.4 Prevalence
4.5 Screening for autonomic neuropathy
4.6 Clinical syndromes
4.7 Conclusion

5. Diabetes and Sexual Health

5.1 Male erectile dysfunction
5.2 Aetiology
5.3 Assessment of the diabetic male with ED
5.4 Discussion and counselling
5.5 Management of ED in the diabetic male
5.6 Conclusions
5.7 Sexual dysfunction in the female with diabetes

6. Diabetes and the Heart

6.1 Introduction
6.2 Nature of the problem
6.3 Primary prevention of heart disease in diabetes
6.4 Management of heart disease in diabetes
6.5 Secondary prevention of heart disease in diabetes
6.6 Conclusions

7. Diabetes and the Brain

7.1 Introduction
7.2 Cerebrovascular disease and diabetes
7.3 Primary prevention of stroke in diabetes
7.4 Secondary stroke prevention
7.5 Management of acute stroke in diabetic patients
7.6 Diabetes and cognitive function
7.7 Summary

8. Diabetes and the Gastrointestinal System

8.1 Introduction
8.2 Epidemiology
8.3 Pathophysiology of GI dysfunction
8.4 Oesophageal complications
8.5 Stomach complications
8.6 Small intestine
8.7 Colon
8.8 Anorectal function
8.9 Pancreatic
8.10 Hepatobiliary
8.11 Biliary disorders
8.12 Diabetic diarrhoea
8.13 Conclusion

9. Diabetes and Musculoskeletal Disease

9.1 Introduction
9.2 Pathophysiology
9.3 Musculoskeletal conditions associated with diabetes
9.4 Upper limb diabetic complications
9.5 Generalized conditions involving the skeletal system in diabetes
9.6 Functional disability in diabetic patients
9.7 Conclusion

10. Diabetes and the Skin

10.1 Introduction
10.2 Necrobiotic disorders
10.3 Necrobiosis lipoidica
10.4 Acanthosis nigricans
10.5 Eruptive xanthomata
10.6 Diabetic thick skin
10.7 Diabetic dermopathy
10.8 Bullosis diabeticorum
10.9 Infections
10.10 Perforating disorders
10.11 Glucagonoma syndrome
10.12 Vitiligo
10.13 Dermatological definitions
10.14 Dermatological therapies

Index

The Metabolic Syndrome by Christopher Byrne, and Sarah Wild Softcover - 432 pages Shipped in CLICK HERE Cat.# JW-END12 $135.45 BUY Published:  2005    ISBN:  9780470025116

Award-winning!  Highly Commended Certificate of the 2006 BMA Medical Book Competition

The metabolic syndrome is a highly prevalent condition that affects a considerate number of adults and has become increasingly relevant to many disciplines in clinical medicine. This title examines the pathogenesis of metabolic syndrome and its relationship with diabetes and coronary heart disease (CHD), and reviews different treatment options. It covers all aspects of the metabolic syndrome and its constituent diseases.

The editors of this key title, Christopher D. Byrne, a diabetologist and clinician scientist, and Sarah H. Wild, an epidemiologist and public health physician, have brought together a group of authors, all of who are leading researchers in their field.

The editors and chapter authors of this outstanding reference work have each contributed to chapters addressing ‘hot topics’ relevant to the metabolic syndrome. The state-of-the-art chapters range from aetiology to pathogenesis, complications and treatment, addressing subjects such as the developmental origins of the metabolic syndrome, oxidation, inflammation and exciting new areas such as non-alcoholic steatohepatitis and adipocytokines.

The Metabolic Syndrome is an invaluable resource for all clinical researchers and physicians requiring detailed up-to-date information on the metabolic syndrome. It is helpful to further their own research or to treat and manage the syndrome and its complications. The book is also of interest for all health care professionals.

From the reviews:

“[This book] is an excellent collection of updated reviews, and it provides a valuable background for understanding many aspects of this fascinating cluster of risk factors..." NEW ENGLAND JOURNAL OF MEDICINE

Table of Contents:

Preface
List of Contributors

1. The Global Burden of the Metabolic Syndrome and its Consequences for Diabetes and Cardiovascular Disease

Introduction
Definition of the metabolic syndrome
Available data on prevalence of the metabolic syndrome
Factors that influence prevalence of the metabolic syndrome and variation between populations
Interpretation of data on prevalence of the metabolic syndrome
Summary of available data
Pathogenesis of the metabolic syndrome
Consequences of the metabolic syndrome
Conclusions
References

2. Ethnicity and the Metabolic Syndrome

Introduction
The metabolic syndrome and ethnicity
Epidemiology of ethnic differences in the risk for cardiovascular disease
Association between the metabolic syndrome, cardiovascular disease and ethnicity
Potential mechanisms for ethnic differences in the metabolic syndrome
Lessons and challenges of study of ethnicity in terms of disease risk
Clinical implications
Conclusions
References

3. Developmental Origins of Vascular Dysfunction and Disease

Introduction
Endothelial cell function
Endothelial dysfunction
Epidemiology
Experimental evidence
Opportunities for intervention and screening
Conclusions
References

4. Developmental Origins of Insulin Resistance and Type 2 Diabetes

Introduction
Thrifty phenotype hypothesis
Foetal insulin hypothesis
Human studies
Animal studies
Hormonal insults
Surgical intervention
Nutritional models of early growth restriction
Conclusions
References

5. Recent Progress in the Identification of Genes Predisposing to the Metabolic Syndrome

Introduction
Genes known for many of the monogenic components of the metabolic syndrome
Genetic component to common diseases of the metabolic syndrome: genes have proved difficult to find compared with monogenic diseases of the metabolic syndrome
Finding the genes that predispose to diseases of the metabolic syndrome: to improve understanding of the aetiology and treatment
Improved clinical resources, new technology and the human genome project: helping the quest to find genes influencing metabolic syndrome diseases
Genes known to alter the risk of metabolic syndrome diseases
Conclusion
References

6. Atherothrombosis and the Metabolic Syndrome

Introduction
The metabolic syndrome: interaction with coagulation and fibrinolysis
Insulin resistance and endothelial dysfunction
The haemostatic mechanism
The haemostatic mechanism and insulin resistance
Plasminogen activator inhibitor-1
Tissue plasminogen activator
Factor VII
von Willebrand factor and factor VIII
Fibrinogen
Factor XII
Factor XIII B-subunit
Platelets and the metabolic syndrome
Summary and conclusions
References

7. Oxidative Stress, Insulin Resistance and Cardiovascular Disease

Introduction
From overfeeding to insulin resistance: the role of oxidative stress
Oxidative stress as a common pathogenic factor for the dysfunction of beta and endothelial cells
From insulin resistance to impaired glucose tolerance: the role of oxidative stress
From impaired glucose tolerance to diabetes and endothelial dysfunction
The possible link between oxidative stress and inflammation in insulin resistance, diabetes and cardiovascular disease
Oxidative stress as the connection between nutrition overload and diabetes and related cardiovascular complications: therapeutic implications
References

8. Inflammation, Cardiovascular Disease and the Metabolic Syndrome

Introduction
Role of inflammation in atherosclerosis
Relation between inflammation and endothelial function in humans
Role of acute-phase response in atherosclerosis
Is C-reactive protein mechanistically linked to atherosclerosis?
Inflammatory markers as predictors of cardiovascular disease
Inflammation and insulin resistance
Inflammatory markers as predictors of the metabolic syndrome and its components
Lifestyle and drug interventions
References

9. Adipocytokines and the Pathogenesis of the Metabolic Syndrome

Introduction
Adipocytokines and the metabolic syndrome
Summary and perspective
References

10. Peripheral Arterial Disease

Introduction
Definition and pathogenesis of peripheral arterial disease
Clinical spectrum
Descriptive epidemiology
Relation of peripheral arterial disease to ischaemic heart disease and stroke
Risk factors for peripheral arterial disease in relation to the metabolic syndrome
The metabolic syndrome and peripheral arterial disease
Conclusion
References

11. Non-alcoholic Steatohepatitis

Introduction
Aetiology
Diagnosis
Pathogenesis
Treatment
References

12. Polycystic Ovary Syndrome

Introduction
Insulin resistance in polycystic ovary syndrome and its role in reproductive abnormalities
Insulin resistance and metabolic features in women with polycystic ovary syndrome
Mechanisms to lessen diabetes and vascular risk in women with polycystic ovary syndrome
Future research questions in relation to long-term diabetes and vascular risk in polycystic ovary syndrome
Conclusion
References

13. Nutrition: its Relevance in Development and Treatment of the Metabolic Syndrome

Introduction
Weight loss and energy balance
Dietary fat and insulin sensitivity
Dietary fibre and the glycaemic index
Dietary patterns
Conclusions
References

14. Growth Hormone, Exercise and Energy Expenditure in the Metabolic Syndrome

Introduction
Description of growth hormone/insulin-like growth factor axis
The growth hormone/insulin-like growth factor-I system and the metabolic syndrome
Exercise and the metabolic syndrome
Therapeutic potential of the growth hormone/insulin-like growth factor-I axis
Conclusion
References

15. Treatments for the Metabolic Syndrome

Introduction
Targets for treatment
Treatment by lifestyle modification
Medical treatment of the metabolic syndrome
Polypharmacy in the treatment of the metabolic syndrome
Conclusions
References
Index

Isotope Tracers in Metabolic Research: Principles and Practice of Kinetic Analysis (Ed.2) by Robert R. Wolfe, and David L. Chinkes Hardcover - 488 pages Shipped in CLICK HERE Cat.# JW-END13 $226.35 BUY Published:  2004   ISBN:  9780471462095

In the past few years, the number of applications of tracers for in vivo biomedical studies has greatly increased. New analytical tools at the genetic and protein levels have spurred this growth, opening the door for a deeper understanding of metabolic events. This in turn promises to yield significant advances in the understanding and treatment of human disease.

Now fully revised and expanded, Isotope Tracers in Metabolic Research, Second Edition is the established definitive text on stable and radioactive isotope tracers. In unique, multidisciplinary fashion, it presents comprehensive coverage of new methodological, mathematical, and theoretical approaches.

This new Second Edition includes:

• All-new chapters on nuclear magnetic resonance, mass isotopomer analysis, and methods of protein metabolism analysis
• A completely updated categorized list of over 750 references
• Major advances in the development of mass isotopomer and positional isotopomer techniques, noninvasive isotope techniques for studying metabolic pathways, hyphenated techniques, and new tracer techniques
• The latest developments in quantification of DNA synthesis and mass spectrometry spurred by genome sequencing and proteomics
• New coverage of mathematical modeling
• Expanded coverage of microdialysis probes, laboratory procedures, and regulatory issues related to human studies

In this complete guide to performing tracer studies, the authors systematically cover tracer selection, modeling considerations, sample derivitization, mass spectrometry analysis, and data interpretation. Problems and discussion questions highlight key points in each chapter. Isotope Tracers in Metabolic Research, Second Edition offers students and researchers a comprehensive, practical resource for utilizing the latest tracer methodologies.

Table of Contents:

Preface

Chapter 1. Basic Characteristics of Isotopic Tracers
Chapter 2. Calculating Specific Activity and Radiation Dosages
Chapter 3. Calculation of Substance Kinetics: Single-Pool Model
Chapter 4. Calculation of Substrate Kinetics: Multiple-Pool Model
Chapter 5. Mass Spectrometry: Instrumentation
Chapter 6. Determination of Isotopic Enrichment
Chapter 7. Measurement of Substrate Oxidation
Chapter 8. Measurement of Total Energy Expenditure Using the Doubly Labeled Water Method
Chapter 9. Mass Isotopomer Distribution Analysis
Chapter 10. Glucose Metabolism
Chapter 11. Lipid Kinetics
Chapter 12. Whole Body Protein Synthesis and Breakdown
Chapter 13. Measurement of the Synthesis of Specific Proteins
Chapter 14. Measurement of Regional or Tissue Protein Breakdown
Chapter 15. Arterial-Venous Balance Technique to Measure Amino Acid Kinetics
Chapter 16. Nuclear Magnetic Resonance

Glossary
Abbreviations
Index

Biology of IGF-1: Its Interaction with Insulin in Health and Malignant States by Novartis Softcover - 288 pages Shipped in CLICK HERE Cat.# JW-END14 $177.25 BUY Published:  2004   ISBN:  9780470869987

An invaluable book containing a series of interdisciplinary discussions between clinical and basic scientists. Biology of IGF-1: Its interaction with insulin and health and malignant states focuses on key issues such as:

• the definition of danger zones
• the development of methods for early recognition of malignant states linked to IGF-1 and/or insulin
• possible approaches to preventative intervention
• the relevance in this field of research to the development of novel therapeutic approaches to treating certain cancers.

Table of Contents:

Chair's Introduction

1. Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse
2. Physiology of the IGF system
3. Molecular basis of insulin action
4. IGF-1 and insulin as growth hormones
5. Insulin-like growth factors and neoplasia
6. Loss of IGF2 imprinting: mechanisms and consequences
7. Insulin and IGF-1 receptor trafficking and signalling
8. The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb
9. Structural biology of insulin and IGF-1 receptors
10. Genetic blockade of the insulin-like growth factor-I receptor for human malignancy
11. IGF-1 and prostate cancer
12. Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence 13. IGF-1 and breast cancer
14. IGFBPs and cancer
15. The IGF receptor as anti-cancer treatment target

Final discussion
Index of contributors
Subject index

Gastrointestinal Function in Diabetes Mellitus by Michael Horowitz, and Melvin Samsom Softcover - 364 pages Shipped in CLICK HERE Cat.# JW-END15 $177.25 BUY Published:  2004   ISBN:  9780471899167

Gastrointestinal function represents an important, and hitherto inappropriately neglected, aspect of diabetes management. Disordered gastrointestinal motor and sensory function occurs frequently in both type 1 and type 2 diabetes and may be associated with gastrointestinal symptoms that adversely affect quality of life.

During the last two decades there has been a rapid expansion in knowledge in this area. It is now recognised that upper gastrointestinal motility is pivotal to the regulation of postprandial blood glucose concentrations in both health and patients with diabetes. This book is the first of its kind and was stimulated by the need to consolidate these recent advances, which dictate that a knowledge of gastroenterology as it relates to diabetes is now required of the clinician/diabetologist.

• Features an organ-specific overview of the epidemiology and pathophysiology of disordered gastrointestinal (including hepatobiliary and pancreatic) function in diabetes mellitus
• Contains guidelines for the clinician, diabetologist and gastroenterologist for both diagnosis and management
• Includes a comprehensive description of the relation between gastrointestinal function, gastrointestinal hormones, autonomic nerve function and glycaemic control in animal models
• Covers the development of new treatment options, particularly those targeted at the reduction of postprandial hyperglycaemia, to optimise glycaemic control

This book will be of interest to gastroenterologists, diabetologists, specialist nurses and clinical researchers.

Table of Contents:

Preface
List of Contributors

1. Epidemiology of Disordered Gastrointestinal Function and Impact of Chronic Gastrointestinal Symptoms on Quality of Life in Diabetes Mellitus
2. Effects of Diabetes Mellitus on Gastrointestinal Function in Animal Models
3. Oesophageal Function in Diabetes
4. Gastric Function in Diabetes
5. Intestinal Function in Diabetes Mellitus
6. Anorectal Function in Diabetes Mellitus
7. Hepato-billary and Pancreatic Function
8. Impact of Gastrointestinal Function on Glycaemic Control
9. Evaluation of Gastrointestinal Autonomic Function

Index