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Computational Toxicology: Risk Assessment for Pharmaceutical and Environmental Chemicals by Sean Ekins Hardcover - 814 pages Shipped in CLICK HERE Cat.# JW-TOX1 $162.70 BUY Published:  2007    ISBN:  9780470049624

A comprehensive analysis of state-of-the-art molecular modeling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals

This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with:

• An introduction to toxicology methods and an explanation of computational methods
• In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels
• Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena
• Chapters written by leading international experts
• Figures that illustrate computational models and references for further information

This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development.

Table of Contents:

Series Introduction
Preface
Acknowledgments
Contributors

PART I: INTRODUCTION TO TOXICOLOGY METHODS

1. An Introduction to Toxicology and Its Methodologies
2. In Vitro Toxicology: Bringing The In Silico and In Vivo World Closer
3. Physiologically-Based Pharmacokinetic/Pharmacodynamic Modelling
4. Cross-Species Differences In Receptor-Mediated Gene Regulation
5. Toxicogenomics and Systems Toxicology

PART II: COMPUTATIONAL METHODS

6. Toxicoinformatics: An Introduction
7. Computational Approaches for Assessment of Toxicity - A Historical Perspective and Current Status
8. Current QSAR Techniques for Toxicology

PART III. APPLYING COMPUTERS TO TOXICOLOGY ASSESSMENT: PHARMACEUTICAL

9. The Prediction of Physicochemical Properties
10. Applications of QSAR to Enzymes Involved In Toxicology
11. QSAR-Studies on Drug Transporters Involved In Toxicology
12. Applications Of QSAR To Receptors Involved In Toxicology
13. Applications Of QSAR Methods To Ion Channels
14. Predictive Mutagenicity Computer Models
15. Novel Applications of Kernel-Partial Least Squares to Modelling A Comprehensive Array Of Properties For Drug Discovery
16. Homology Models Applied To Toxicology
17. Crystal Structures Of Toxicology Targets
18. Expert Systems
19. Strategies for Using Computational Toxicology Methods in Pharmaceutical R&D
20. Application of Interpretable Models to ADME/TOX Problems

PART IV APPLYING COMPUTERS TO TOXICOLOGY ASSESSMENT: ENVIRONMENTAL.

21. The Toxicity and Risk of Chemical Mixtures
22. Environmental and Ecological Toxicology - Computational Risk Assessment
23. Application of QSARs In Aquatic Toxicology
24. Dermatotoxicology: Computational Risk Assessment

PART V. NEW TECHNOLOGIES FOR TOXICOLOGY, FUTURE AND REGULATORY PERSPECTIVES 

25. Novel Cell Culture Systems - Micro And Nanotechnology For Toxicology
26. Future of Computational Toxicology: Broad Application into Human Disease and Therapeutics
27. Computational Tools for Regulatory Needs

Chemical Warfare Agents: Toxicology and Treatment (Ed.2) by Timothy Marrs, Robert Maynard, and Frederick Sidell Hardcover - 750 pages Shipped in CLICK HERE Cat.# JW-TOX2 $399.95 BUY Published:  2007    ISBN:  9780470013595

Chemical Warfare Agents, Second Edition has been totally revised since the successful first edition and expanded to about three times the length, with many new chapters and much more in-depth consideration of all the topics. The chapters have been written by distinguished international experts in various aspects of chemical warfare agents and edited by an experienced team to produce a clear review of the field.

The book now contains a wealth of material on the mechanisms of action of the major chemical warfare agents, including the nerve agent cyclosarin, formally considered to be of secondary importance, as well as ricin and abrin. Chemical Warfare Agents, Second Edition discusses the physico-chemical properties of chemical warfare agents, their dispersion and fate in the environment, their toxicology and management of their effects on humans, decontamination and protective equipment. New chapters cover the experience gained after the use of sarin to attack travellers on the Tokyo subway and how to deal with the outcome of the deployment of riot control agents such as CS gas.

This book provides a comprehensive review of chemical warfare agents, assessing all available evidence regarding the medical, technical and legal aspects of their use. It is an invaluable reference work for physicians, public health planners, regulators and any other professionals involved in this field.

Review of the First Edition:

"What more appropriate time for a title of this scope than in the post 9/11 era? ...a timely, scholarly, and well-written volume which offers much information of immense current and…future benefit." VETERINARY AND HUMAN TOXICOLOGY

Table of Contents:

List of contributors
Preface

1. Opinions of Chemical Warfare
2. Physico-Chemical Properties of Chemical Warfare Agents
3. Dispersion and Modelling of the Spread of CW Agents
4. Chemical Warfare Agent Degradation
5. Detection of Chemical Warfare Agents in Biological Samples
6. Respiratory Protection
7. Responding to chemical terrorism
8. Toxicology of Nerve Agents
9. A History of Human Studies with Nerve Agents
10. The Effects of Exposure to Low Doses of Nerve Agents
11. Managing Casualties Affected by Nerve Agents
12. The Management of Casualties following Toxic Agent Release
13. The Tokyo Experience 14. Atropine and Other Anticholinergic Drugs
15. Oximes
16. Diazepam
17. Pretreatment of Nerve Agent Poisoning
18. Gulf War Syndrome
19. The General Toxicology of Mustard Gas
20. Dermal Aspects of Chemical Warfare Agents
21. Managing Skin Lesions
22. Management of Bone Marrow Depression
23. Toxicology of Arsenic Compounds
24. Toxicology of Phosgene and Treatment of Phosgene Exposure
25. Cyanides
26. Riot Control Agents
27. Ricin and Abrin
28. Disarmament
29. A-Z of Toxic Compounds

Chromatographic Methods in Clinical Chemistry and Toxicology by Roger Bertholf, and Ruth Winecker Hardcover - 308 pages Shipped in CLICK HERE Cat.# JW-TOX3 $173.60 BUY Published:  2007   ISBN:  9780470023099

This book aims to fill the gap that exists between theoretical treatments of chromatography, and clinical chemistry and toxicology texts, which focus almost exclusively on clinical relevance and applications. Chromatography has a vast array of clinical applications, and though the chromatographic methods were first introduced decades ago, new applications of this technology are being used to explore previously inaccessible frontiers in clinical diagnostics and toxicological testing. An up-to-date book devoted to clinical and toxicological applications of chromatographic methods will serve as an instructional and reference text, useful to students, laboratory technicians, and researchers.

Table of Contents:

Preface
List of Contributors

1. Quality Assurance, Quality Control and Method Validation in Chromatographic Applications

1.1 Introduction
1.2 History
1.3 Definition of Quality Assurance and Quality Control
1.4 Professional Organizations
1.5 Internal Quality Assurance and Control
1.5.1 Standard operating procedure manual
1.5.2 Method development
1.5.3 Method validation
1.5.4 Accuracy
1.5.5 Precision
1.5.6 Recovery
1.5.7 Lower limits of detection (sensitivity) and quantitation
1.5.8 Range of linearity
1.5.9 Specificity
1.5.10 Stability
1.5.11 Carryover
1.5.12 Ruggedness
1.5.13 Selection of a reference standard
1.5.14 Selection of an internal standard and standard addition
1.5.15 Selection of derivatization agent
1.5.16 Selection of ions for selected-ion monitoring or full-scan analysis
1.5.17 Chromatographic performance
1.5.18 Statistical evaluation of quality control
1.6 External Quality Assurance

References

2. Liquid Chromatographic-Mass Spectrometric Measurement of Anabolic Steroids

2.1 Introduction
2.2 LC-MS Analysis of Synthetic Steroids or Animal Samples
2.3 LC-MS Analysis of Natural Androgens in Human Samples
2.4 Conclusion

References

3. High-performance Liquid Chromatography in the Analysis of Active Ingredients in Herbal Nutritional Supplements

3.1 Introduction
3.2 St John’s Wort
3.2.1 Drug interactions with St John’s wort
3.2.2 Measurement of active ingredients of St John’s wort using HPLC
3.2.3 Analysis of St John’s wort extract with other analytical techniques
3.2.4 Measurement of hypericin and hyperforin in human plasma using HPLC
3.3 Herbal Supplements with Digoxin-like Immunoreactivity
3.3.1 Use of HPLC for the determination of chan su, danshen and ginsengs
3.4 Herbal Remedies and Abnormal Liver Function Tests
3.4.1 Use of GC-MS and HPLC for the measurement of active components
3.5 Ginkgo Biloba
3.5.1 Analysis of components of ginkgo biloba by HPLC
3.6 Echinacea
3.6.1 Analysis of active components of echinacea by HPLC
3.7 Valerian
3.7.1 Analysis of components of valerian by HPLC
3.8 Feverfew
3.8.1 Analysis of parthenolide by HPLC
3.9 Garlic
3.9.1 Measurement of components of garlic by HPLC
3.10 Ephedra (Ma Huang) and Related Drugs
3.10.1 Analysis of active components of ephedra-containing products
3.11 Conclusions

References

4. Measurement of Plasma L-DOPA and L-Tyrosine by High-Performance Liquid Chromatography as a Tumor Marker in Melanoma

4.1 Introduction
4.2 Melanogenesis
4.2.1 Overview of the pathway
4.2.2 Potential tumor markers
4.3 L-DOPA Alone
4.3.1 Urine analysis
4.3.2 Blood (plasma or serum) analysis
4.4 L-DOPA/L-Tyrosine Ratio
4.4.1 Technical aspects
4.4.2 Clinical results
4.4.3 Future directions
4.5 Conclusion

References

5. Hypersensitive Measurement of Proteins by Capillary Isoelectric Focusing and Liquid Chromatography-Mass Spectrometry

5.1 Introduction
5.2 A Robust CIEF-RPLC Interface
5.3 First-Generation CIEF-RPLC-MS System for Proteins
5.4 Second-Generation CIEF-RPLC-MS System
5.5 Future Improvements

Acknowledgment
References

6. Chromatographic Measurement of Transferrin Glycoforms for Detecting Alcohol Abuse and Congenital Disorders of Glycosylation

6.1 Introduction
6.2 Transferrin Microheterogeneity
6.3 Carbohydrate-deficient Transferrin (CDT)
6.4 Congenital Disorders of Glycosylation (CDG)
6.5 Analytical Methods for Transferrin Microheterogeneity
6.6 Chromatographic Methods for CDT
6.6.1 HPLC conditions and potential interferences
6.6.2 Chromatographic separation of transferrin glycoforms
6.6.3 Genetic transferrin variants and glycoform types
6.6.4 Sensitivity and reproducibility
6.7 Chromatographic Methods for CDG
6.7.1 HPLC testing for CDG
6.7.2 LC-MS testing for CDG
6.8 Summary and Conclusion

References

7. Chromatographic Measurements of Catecholamines and Metanephrines

7.1 Background
7.1.1 Total or individual assays
7.2 Analytical Measurements of Catecholamines and Metanephrines
7.3 Early Methods
7.3.1 Catecholamines
7.3.2 Metanephrines
7.4 Current Chromatographic Methods
7.4.1 Chemistry of catecholamines
7.4.2 Specimen preparation
7.4.3 Fluorescence detection
7.4.4 Electrochemical detection
7.4.5 Chemiluminescence detection
7.4.6 Mass spectrometry
7.5 Practical Considerations for the Stability of Urinary Catecholamines and Metanephrines During Storage
7.6 Future Developments

Dedication
References

8. Chromatographic Measurement of Volatile Organic Compounds (VOCs)

8.1 Introduction
8.2 General Considerations
8.3 Intended Use
8.4 Volatility of Compounds
8.5 Sample Collection, Handling and Storage
8.6 Headspace Gas Chromatographic Methods
8.7 Columns and Detectors
8.8 Identification, Quantitation and Confirmation
8.9 Ethanol and Other Volatile Alcohols
8.10 Inhalants and Screening for Multiple VOCs
8.11 Interpretation
8.12 Conclusion

References

9. Chromatographic Techniques for Measuring Organophosphorus Pesticides

9.1 Introduction
9.2 Organophosphorus Pesticides (OPs)
9.2.1 Mechanism of action
9.2.2 Intoxication
9.2.3 Progression of intoxication and longer term risks
9.2.4 Therapy
9.2.5 Analytical procedures
9.3 Conclusion

References

10. Chromatographic Analysis of Nerve Agents

10.1 Introduction
10.2 Neuromuscular Blockers
10.2.1 Background and uses
10.2.2 Classification, mechanism and duration of action
10.2.3 Effects and toxicity
10.2.4 Analysis
10.3 Paralytic Shellfish Poisoning: Saxitoxin
10.3.1 Background
10.3.2 Toxicity
10.3.3 Analysis
10.4 Summary

References

11. History and Pharmacology of c-Hydroxybutyric Acid

11.1 Introduction
11.2 History of Illicit Use of GHB
11.3 Clinical Use of GHB in Humans
11.4 History of Illicit Use of GBL and 1,4BD
11.5 Distribution and Pharmacokinetics of GHB, GBL and 1,4BD
11.6 GHB Interpretation Issues and Post-mortem Production
11.7 Analysis for GHB, GBL and 1,4BD

References

12. Liquid Chromatography with Inductively Coupled Plasma Mass Spectrometric Detection for Element Speciation: Clinical and Toxicological Applications

12.1 Introduction
12.2 Liquid Chromatography with Inductively Coupled Plasma Mass Spectrometric Detection
12.3 Analytical Applications of Clinical and Toxicological Relevance
12.3.1 Arsenic
12.3.2 Iodine
12.3.3 Mercury
12.3.4 Platinum
12.3.5 Selenium
12.4 Conclusions and Future Trends
12.5 Abbreviations

References

13. Applications of Gas Chromatography-Mass Spectrometry to the Determination of Toxic Metals

13.1 Introduction
13.2 Instrumentation
13.3 Experimental Procedure
13.3.1 Preparation of internal standard solutions
13.3.2 Digestion of biological sample
13.3.3 Preparation of metal chelate
13.4 GC-MS Studies
13.4.1 Memory effect evaluation
13.4.2 Precision and accuracy in measuring isotope ratios
13.4.3 Results of concentration determination of toxic metals in biological samples
13.5 Conclusions

References
Index

Environmental Toxicants: Human Exposures and Their Health Effects (Ed.2) by Morton Lippmann Hardcover - 1,008 pages Shipped in CLICK HERE Cat.# JW-TOX4 $139.05 BUY Published:  2005   ISBN:  9780471780854

A comprehensive guide to assessing the health effects of environmental
toxicants in nonoccupational settings

Now in a second edition, Environmental Toxicants: Human Exposures and Their Health Effects continues to offer a unique perspective on a topic that is usually focused on exposure and effects in industrial settings. Fully revised and expanded, it presents comprehensive, cutting-edge information on the effects of human exposure to selected chemicals and physical agents in nonoccupational environments. Dr. Morton Lippmann assembles expert contributions by leading authorities on each of the twenty-five environmental agents examined, providing a critical review of the accumulated evidence concerning their known or likely impact on human health, especially after long-term exposure.

Six new chapters have been added to this edition, discussing ambient particulate matter, chromium, mercury, noise, pesticides, and ultraviolet radiation. Existing chapters have been updated to include the most current information on performing risk assessments for established toxicants-from asbestos and benzene to the sick building syndrome. In the closing chapters, the authors place the discussion in a broader social and scientific context, exploring such issues as individual and community risk, environmental engineering for risk reduction, pulmonary medicine, and lessons learned in the industrial sector.

Supplemented with more than 100 illustrations and photographs, and with a view to future research trends, Environmental Toxicants: Human Exposures and Their Health Effects is an indispensable guide for public health officials, industrial hygienists, epidemiologists, and primary care physicians involved in risk assessment and management for exposed individuals and populations.

Table of Contents:

Preface
Contributors

1. Introduction and Background
2. Ambient Particulate Matter
3. Asbestos and Other Mineral and Vitreous Fibers
4. Benzene
5. Carbon Monoxide
6. Chromium
7. Diesel Exhaust
8. Dioxins and Dioxins-like Chemicals
9. Drinking Water Disinfection
10. Environmental Tobacco Smoke
11. Food Constituents, Additives, and Contaminants
12. Formaldehyde and Other Aldehydes
13. Indoor Bioaerosol Contaminants
14. Lead and Compounds
15. Human-made Ionizing Radiation and Radioactivity: Sources, Levels, and Effects
16. Mercury
17. Microwaves and Electromagnetic Fields
18. Nitrogen Oxides
19. Noise: Its Effects and Control
20. Ozone
21. Pesticides
22. Radon and Daughters
23. Sulfur Oxides: Acidic Aerosols and SO2
24. Trace Elements: Aluminum, Arsenic, Cadmium, and Nickel
25. Ultraviolet Radiation
26. Volatile Organic Compounds and the Sick Building Syndrome
27. Perspectives on Individual and Community Risks
28. Reducing Risks: An Environmental Engineering Perspective
29. Clinical Perspective on Respiratory Toxicology
30. Industrial Perspectives: Translating the Knowledge Base into Corporate Policies, Programs, and Practices for Health Protection

Index

Ullmann's Industrial Toxicology by Wiley-vch Hardcover - 1,191 pages Shipped in CLICK HERE Cat.# JW-TOX5 $657.25 BUY Published:  2006    ISBN:  9783527312474

The one-stop resource for health protection professionals,
environmental scientists and safety engineers.

Since the entire 40-volume Ullmann's Encyclopedia is inaccessible to many readers - particularly individuals, smaller companies or institutes - all the information on industrial toxicology, ecotoxicology, process safety as well as occupational health and safety has been condensed into this convenient 2-volume set.

Based on the latest online edition of Ullmann's containing articles never been before in print, this ready reference provides practical information on applying the science of toxicology in both the occupational and environmental setting, and explains the fundamentals necessary for an understanding of the effects of chemical hazards on humans and ecosystems. The detailed and meticulously edited articles have been written by renowned experts from industry and academia, and much of the information has been thoroughly revised. Alongside explanations of safety regulations and legal aspects, this set covers food additives, toxic agents as well as medical and therapeutical issues. Top-quality illustrations, clear diagrams and charts combined with an extensive use of tables enhance the presentation and provide a unique level of detail. Deeper insights into any given area of interest is offered by referenced contributions, while rapid access to a particular subject is enhanced by both a keyword and author index.

Table of Contents:

VOLUME I. Toxicology in Occupational and Environmental Setting

Symbols and Units
Conversion Factors
Abbreviations
Country Codes
Periodic Table of Elements
Toxicology
Ecology and Ecotoxicology
Occupational Health and Safety
Plant and Process Safety
Transport, Handling, and Storage
Chemical Products: Safety Regulations
Legal Aspects

VOLUME 2. TOXIC AGENTS, PHARMACEUTICAL AND MEDICAL FUNDAMENTALS

Carciogenic Agents
Mutagenic Agents
Food Additives
Antioxidants
Disinfectants
Nucleic Acids
Amino Acids
Cancer Chemotherapy
Immunotherapy and Vaccines
Pharmaceuticals, General Survey and Development
Chemotherapeutics
Antimycotics
Neuropharmacology

Author Index
Subject Index

The Toxicology Handbook for Clinician's by Carson R. Harris Hardcover - 368 pages Shipped in CLICK HERE Cat.# EL-TOX1 $ 43.35 BUY Published:  2006    ISBN:  9781560537113

The Toxicology Handbook for Clinician's provides you with quick access to common ingestions youre likely to see in the Emergency Department. Chapters covering Pesticides, Cardiovascular Drugs, Drugs of Abuse, and many more put essential topics right at your fingertips. Each chapter follows a similar organization, making finding information quick and easy when you're on the go.

Table of Contents:

Toxicology Handbook by Lindsay Murray, Frank Daly, Mark Little and Mike Cadogan (Editors) Flexicover - 468 pages Shipped in CLICK HERE Cat.# EL-TOX2 $ 63.60 BUY Published:  2006   ISBN:  9780729537896

AUSTRALIAN AUTHOR

The Toxicology Handbook, is a portable handbook that provides a simple guide to the management of poisonings and envenoming specific to the Australian, New Zealand and South Pacific regions. A didactic guide to the appropriate principles in approach, assessment and management of poisoned patients at point of care.

A Textbook of Modern Toxicology by Ernest Hodgson Hardcover - 584 pages Shipped in CLICK HERE Cat.# JW-TOX6 $115.40 BUY Published:  2004   ISBN:  9780471265085

Toxicology is the science of poisons, embracing the physical and chemical study of all the known poisonous substances, as well as the methods of testing for them, their action on the living body, and the postmortem results they occasion. The Third Edition of this benchmark text once again proves the most authoritative resource on the subject for both students and practicing professionals.

Table of Contents:

Preface
Contributors

PART I: INTRODUCTION

1. Introduction to Toxicology
2. Introduction to Biochemical and Molecular Methods in Toxicology
3. Toxicant Analysis and Quality Assurance Principles

PART II: CLASSES OF TOXICANTS

4. Exposure Classes, Toxicants in Air, Water, Soil, Domestic and Occupational Settings
5. Classes of Toxicants: Use Classes

PART III: TOXICANT PROCESSING IN VIVO

6. Absorption and Distribution of Toxicants
7. Metabolism of Toxicants
8. Reactive Metabolites
9. Chemical and Physiological Influences on Xenobiotic Metabolism
10. Elimination of Toxicants

PART IV: TOXIC ACTION

11. Acute Toxicity
12. Chemical Carcinogenesis
13. Teratogenesis

PART V: ORGAN TOXICITY

14. Hepatotoxicity
15. Nephrotoxicity
16. Toxicology of the Nervous System
17. Endocrine System
18. Respiratory Toxicity
19. Immunotoxicity
20. Reproductive System

PART VI: APPLIED TOXICOLOGY

21. Toxicity Testing
22. Forensic and Clinical Toxicology
23. Prevention of Toxicity
24. Human Health Risk Assessment

PART VII: ENVIRONMENTAL TOXICOLOGY

25. Analytical Methods in Toxicology
26. Basics of Environmental Toxicology
27. Transport and Fate of Toxicants in the Environment
28. Ecological Risk Assessment

PART VIII: SUMMARY

29. Future Considerations for Environmental and Human Health

Glossary
Index