IMMUNOLOGY PUBLICATIONS

Mucosal Immunology Defense: Immunoglobulin A Edited by Charlotte S. Kaetzel Hardcover - 446 pages Shipped in CLICK HERE Cat.# DA-IMM1 $184.50 BUY Published:  2008   ISBN:  9780387722313

Immune responses at mucosal surfaces play a major role in host mucosal defense against microbial pathogens and in the pathogenesis of acute and chronic mucosal inflammatory diseases. This volume draws on a broad spectrum of molecular biologic, biochemical, and immunogenetic approaches in combination with human and murine in vitro cell culture and in vivo model systems to address questions in mucosal immunity. Humans produce more immunoglobulin A (IgA) than all other antibody isotypes combined, most of which is rapidly transported into the external secretions bathing mucous membranes. It has been estimated that more than 3 grams of IgA are transported daily into mucosal secretions, carrying out a wide range of antimicrobial and anti-inflammatory functions. IgA is the second most abundant class of antibody in the bloodstream, contributing to systemic as well as secretory immunity. Recent advances in human genomics, gene regulation, structural biology, cell signaling, and immunobiology have greatly enhanced our understanding of this important class of antibody. This book is designed to serve as a concise reference of the present knowledge of the biology of IgA, including structure of IgA and its interaction with Fc receptors; epithelial transport of IgA; regulation of the mucosal IgA system; biological roles of IgA, including newly discovered functions; IgA-associated diseases, and therapeutic applications for IgA. Chapters have been contributed by internationally recognized leaders in the field of IgA research, representing 8 countries on 3 continents.

Contents: Structure of IgA. IgA Plasma Cell Development. Epithelial Transport of IgA by the Polymeric Immunoglobulin Receptor. Fc Receptors for IgA. Regulation of the Mucosal IgA System. Biological Functions of IgA. Protection of Mucosal Epithelia by IgA: Intracellular Neutralization and Excretion of Antigens. Novel Functions of Secretory IgA. IgA and Antigen Sampling. IgA and Intestinal Homeostasis. IgA and Respiratory Immunity. IgA and Reproductive Tract Immunity. IgA-Associated Diseases. Mucosal SIgA Enhancement: Development of Safe and Effective Mucosal Adjuvants and Mucosal Antigen Delivery Vehicles. Recombinant IgA Antibodies.

The prevalence of allergies, asthma, and related allergic diseases has dramatically increased in recent decades. It is no longer true that only developed countries are affected - these diseases are now placing an enormous strain on the health resources in many developing countries around the world. At the same time, there has been rapid progress in translating molecular science into diagnostic and therapeutic applications. Even with these tremendous developments, large gaps still remain in the way that allergists practice medicine in the office. One of the aims of the Collegium Internationale Allergologicum's biennial symposium and of this book is to bridge this ever-widening gap. Every two years, 200 of the world's leading allergists gather for an intimate and friendly symposium organized by the Collegium Internationale Allergologicum to discuss cutting-edge results of allergy research and future therapeutic options. This volume collects a series of excellent papers presented there, covering topics such as gene-environment interaction, T cell regulation, basic mechanisms of effector cell function, mast cells, psychoneuroallergology, asthma, food allergy, eczema, drug reactions, diagnostics and the latest progress in pharmacotherapy, as well as nonspecific and specific immunotherapy.

Basic Immunology by Abul K. Abbas Textbook - 320 pages Shipped in CLICK HERE Cat.# EL-IMM3 $ 67.25 BUY Published:  2008   ISBN:  9781416046882

Here's a readable and concise introduction to the workings of the human immune system, with emphasis on clinical relevance. The format makes learning easy with short, easy-to-read chapters, color tables, key point summaries, and review questions in every chapter.

• Relates basic science to clinical disorders through clinical cases for better application in a real-world setting.
• Includes a full Glossary to keep you on the cutting edge of immunologic terminology.
• Includes appendices summarizing the features of CD Molecules, a handy Glossary, and Clinical
• Cases that test your understanding of how the immune system functions in health and disease.
• Illustrated with beautiful full-color artwork for enhanced visual learning.

Table of Contents:

1. Introduction to the Immune System
2. Innate Immunity
3. Antigen Capture and Presentations to Lymphocytes
4. Antigen Recognition in the Adaptive Immune System
5. Cell-Mediated Immune Responses
6. Effector Mechanisms of Cell-Mediated Immunity
7. Humoral Immune Responses
8. Effector Mechanisms of Humoral Immunity
9. Immunologic Tolerance and Autoimmunity
10. Immune Responses Against Tumors and Transplants
11. Hypersensitivity Diseases
12. Congenital and Acquired Immunodeficiencies
Suggested Readings
Appendix I: Principal Features of CD Molecules
Appendix II: Glossary
Appendix III: Clinical Cases
Index

Handbook of Tuberculosis: Immunology and Cell Biology by Stefan H. E. Kaufmann, and Warwick J. Britton Hardcover - 460 pages Shipped in CLICK HERE Cat.# JW-IMM10 $235.45 BUY Published:  2008   ISBN:  9783527318872

Tuberculosis (TB), a deadly airborne disease caused by the bacterium Mycobacterium tuberculosis, takes the lives of almost 2 million people each year and is considered to be the most common infectious disease in the world. However, thanks to the efforts of researchers such as the volumes’ lead editor, Dr. Stefan H. E. Kaufmann, there have been several recent advances in fighting the disease.

Dr. Stefan Kaufmann, the Founding Director of the Max Planck Institute for Infection Biology in Berlin and Professor of Microbiology and Immunology at the Charité at the Humboldt University, Berlin, has published more than 600 scientific articles and currently serves as President of the European Federation of Immunological Societies and Chair of the Immunology Division of the American Society of Microbiology. Dr. Kaufmann is considered the world's leading expert in the field of tuberculosis.

The Handbook of Tuberculosis, which explores the causes and available treatments of the widespread infection as well as current research into vaccination, is divided into three separate volumes covering different areas of study. Each volume provides an essential resource to molecular and cell biologists, bacteriologists, immunologists, pathologists and pathophysiologists, clinicians and those working in the pharmaceutical industry and interested in world health.

Volume 1: Molecular Biology and Biochemistry highlights the molecular mechanisms of tuberculosis.

Volume 2: Immunology and Cell Biology is co-edited by Dr. Warwick Britton, Professor of Medicine at the University of Sydney and head of the Mycobacterial Research Program at the Centenary Institute, Sydney, Australia. It presents the pre-eminent resource for all aspects of cell biology and immunology of tuberculosis, including vaccine development.

Volume 3: Clinics, Diagnostics, Therapy and Epidemiology introduces a comprehensive overview of clinical aspects of tuberculosis, including drug resistance, epidemiological aspects and clinical trials.

Table of Contents:

Immunity to M. tuberculosis and BCG: Introduction
Recognition Receptors and Phagocytosis for M. tuberculosis
Transcriptional Response of Macrophages and Dendritic Cells to M. tuberculosis
Dendritic Cells and Antigen Presentation
Killing Mechanisms of the Host Against M. tuberculosis
Manipulation of the Macrophage Response
Conventional T Cells and their Antigenic Repertoire
Unconventional T Cells
Cytokines in Tuberculosis
Antibodies in Tuberculosis
Pathology
Maintenance of Latent Infection with Correlates of Protective Immunity
Genetics of Resistance (mouse and man)
HIV/TB Interactions
Novel Vaccination Strategies Against Tuberculosis
Experimental Animal Models of Tuberculosis

Cellular and Molecular Immunology by Abul Abbas, Andrew Lichtman, and Shiv Pillai Softcover - 572 pages Shipped in CLICK HERE Cat.# EL-IMM2 $114.10 BUY Published:  2007   ISBN:  9781416031222

An exceptionally lucid guide to the latest immunology concepts! Through five best-selling editions, readers worldwide have appreciated this book's in-depth yet straightforward, richly illustrated approach to this complex subject. Now, sweeping updates incorporate the latest discoveries about innate immunity, the organization of lymphoid organs, and many other cutting-edge topics. Plus, online access via STUDENT CONSULT makes this an even more powerful learning resource!

• Clearly explains the experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels - and the conclusions that can be drawn from those observations.
• Highlights the implications of immunologic science for the management of human disease, emphasizing the clinical relevance of the material.

Section I. Introduction to the Immune System

Chapter 1. Properties and Overview of Immune Responses
Chapter 2. Innate Immunity
Chapter 3. Cells and Tissues of the Adaptive Immune System

Section II. Recognition of Antigens

Chapter 4. Antibodies and Antigens
Chapter 5. The Major Histocompatibility Complex
Chapter 6. Antigen Processing and Presentation to T Lymphocytes
Chapter 7. Antigen Receptors and Accessory Molecules of T Lymphocytes

Section III. Maturation, Activation and Regulation of Lymphocytes

Chapter 8. Lymphocyte Development and the Rearrangement and Expression of Antigen Receptor Genes
Chapter 9. Activation of T Lymphocytes
Chapter 10. B Cell Activation and Antibody Production
Chapter 11. Immunologic Tolerance

Section IV. Effector Mechanisms of Immune Responses

Chapter 12. Cytokines
Chapter 13. Effector Mechanisms of Cell-Mediated Immunity
Chapter 14. Effector Mechanisms of Humoral Immunity

Section V. The Immune System in Defense and Disease

Chapter 15. Immunity to Microbes
Chapter 16. Transplantation Immunology
Chapter 17. Immunity to Tumors
Chapter 18. Diseases Caused by Immune Responses: Hypersensitivity and Autoimmunity
Chapter 19. Immediate Hypersensitivity
Chapter 20. Congenital and Acquired Immunodeficiencies
Appendix I: Glossary
Appendix II: Principal Features of Selected CD Molecules
Appendix III: Laboratory Techniques Commonly Used in Immunology

Neuroimmunology in Clinical Practice by Bernadette Kalman, and Thomas H. Brannagan III Hardcover - 280 pages Shipped in CLICK HERE Cat.# JW-IMM11 $173.65 BUY Published:  2007   ISBN:  9781405158404

Written by field experts, Neuroimmunology in Clinical Practice fills a void in traditional neuroimmunology literature, which tends to cover the discipline’s scientific aspects with little emphasis on clinical applications. This unique book is essential reading in clinical neuroimmunology.

• Written by field experts this book provides a comprehensive description of immune mediated neurological disorders complemented with the most pertinent and up to date scientific data
• Covers inflammatory demyelination in the central nervous system, autoimmune diseases of the peripheral nervous system and the muscle, and disorders of the central and peripheral nervous systems
• Fills a gap in existing neuroimmunology literature by focusing on clinical applications

Table of Contents:

Preface
Foreword
Contributing Authors

Part I: Basic Science Introduction to Clinical Neuroimmunology

1. The basics of cellular and molecular immunology
2. Major components of myelin in the mammalian central and peripheral nervous systems

Part II: Inflammatory Demyelination in the Central Nervous System

3. Multiple sclerosis
3.1 Epidemiology and genetics
3.2 Immunopathogenesis
3.3 Courses and diagnosis of MS
3.4 Clinical features
3.5 The pathology of MS: a quest for clinical correlation
3.6 Cerebrospinal fluid
3.7 Magnetic resonance imaging characteristics of MS
3.8 Treatment of MS
4. Devic’s disease
5. Acute disseminated encephalomyelitis and related conditions

Part III: Autoimmune Diseases of the Peripheral Nervous System and the Muscle

6. Guillain-Barre Syndrome I
7. Immune mediated chronic demyelinating polyneuropathies
8. Immune mediated autonomic neuropathies
9. Autoimmune myasthenic syndromes: myasthenia gravis and Lambert-Eaton myasthenic syndrome
10. Polymyositis and dermatomyositis

Part IV: Disorders of the Central and Peripheral Nervous Systems Related to Known or Assumed Systemic Immune Abnormalities

11. Neuro-Sjögren's syndrome
12. Neuro-Behcet's syndrome
13. Steriod responsive encephalopathy associated with Hashimoto's thyroiditis
14. Rasmussen encephalitis
15. Susac’s syndrome
16. Cogan’s syndrome
17. Neurosarcoidosis
18. Anti-VGKC syndromes: Isaac's syndrome, Morvan syndrome and Autoimmune limbic encephalitis
19. Paraneoplastic neurological autoimmunity
20. Vasculitis and connective tissue disorders
21. Post-streptococcal movement disorders
22. Neurological manifestations of gluten sensitivity
23. Anti-GAD associated neurological diseases

Index

Immune Dysfunction and Immunotherapy in Heart Disease by Ronald Ross Watson, and Douglas Larson Hardcover - 328 pages Shipped in CLICK HERE Cat.# JW-IMM12 $193.65 BUY Published:  2007   ISBN:  9781405155687

Current heart failure therapeutics affects symptoms without appreciably reducing the mortality rate of 50 0n five years - suggesting a failure in treating the underlying mechanism. This book proposes a new mechanism for heart failure; immune mediated cardiac remodelling for cardiac dysfunction.

The outstanding editor team of two internationally recognized immunologists -- Ronald Watson, who has studied heart disease in immune dysfunction for a decade and has a patent for an immunotherapy of heart disease by immune regulation, and Douglas Larson, whose experience in cardiac transplantation immunology has provided the foundation for research into novel therapeutics for heart failure and hypertension – makes Immune Dysfunction and Immunotherapy in Heart Disease the definitive reference to the state of the science in this area.

The four parts of the book address:

• Immune Dysfunction Leading to Heart Disease: Induction by Physiological Changes
• Immune Dysfunction Promoting CVD: Induction by Transplantation Drugs
• Immune Dysfunction Leading to Heart Dysfunction: Induction or Prevention by Cardiotherapeutic Drugs
• Immune Dysfunction Leading to Heart Disease: Induction by Pathogens

Both researchers and practitioners will find this authoritative volume an excellent source of information on novel immune targeted therapeutics.

Table of Contents:

Contributors
Preface
About the Editors

Part I: Immune dysfunction leading to heart disease: induction by physiological changes

1. Immunosuppression by ultraviolet light-B radiation: amediator of cardiac remodeling
2. Immune mechanisms in pediatric cardiovascular disease
3. Heart failure–role of autoimmunity
4. Immune basis of hypertension in humans
5. Immune dysregulation: potential mediator of metabolic syndrome-induced cardiac remodeling
6. T helper 2 cell cytokines in remodeling of aortic wall
7. Effects of TNF- on cardiac function
8. Immunosuppression in promotion of cardiac allograft vasculopathy
9. Immunotherapy for left ventricular dysfunction after heart transplantation

Part II: Immune dysfunction promoting CVD: induction by transplantation drugs

10. Immunomodulating therapy in chronic heart failure
11. Statins in atherosclerosis: role of immune regulation
12. ACE inhibitors as immunomodulators: treatment of cardiovascular disease
13. Treatment of heart failure by anticytokine therapies

Part III: Immune dysfunction leading to heart dysfunction: induction or prevention by cardiotherapeutic drugs

14. Pathogenesis of cardiovascular complications in the acquired immunodeficiency syndrome
15. Cytokines and T cell-mediated responses in autoimmune myocarditis
16. Drugs of abuse: accentuation of immunomodulation of viral myocarditis

Part IV: Immune dysfunction leading to heart disease: induction by pathogens

17. Osteopontin: the link between the immune system and cardiac remodeling.
18. Inflammatory immune activation in heart failure patients: therapeutic implications
19. Role of innate immune dysregulation in diabetic heart failure
20. Tolerance in heart transplantation: current and future role
21. Neutralization of Th2 cytokines in therapy of cardiovascular pathology
22. Anti-inflammatory immune therapy in heart disease
23. Cholesterol, interleukin-6 inflammation, and atherosclerosis - role of statins, bisphosphonates, and plant polyphenols in atherosclerosis and other diseases of aging
24. Autoimmune myocarditis: treatment with anti-T-cell antibodies
25. Immunosuppressive therapy to counter cardiac allograft vasculopathy
26. Role of oral pathogens in the pathogenesis of coronary heart disease
27. Myocardial regenerative potential by stem cell transplant
28. Bioflavanoids and dietary anti-inflammatory actions: role in cardiovascular diseases

Index

Immunology - From Cell to Disease by Robert A. Meyers Hardcover - 465 pages Shipped in CLICK HERE Cat.# JW-IMM1 $273.65 BUY Published:  2007   ISBN:  9783527317707

Immunology is the area of life science concerned with how an organism fights infection and disease. To defend itself, the body makes use of the immune system, a complex set of specialised cells and organs that cooperate together to fight disease. This involves protecting us against invading bacteria and viruses, eliminating other foreign substances from the body, and destroying cancer cells. As the immune system is so important, diseases of the system can often be fatal - for example HIV/AIDS.

With an editorial board containing 11 Nobel laureates, this invaluable collection of high-quality articles on immunology is taken from the successful Meyer's Encyclopedia of Molecular Cell Biology and Molecular Medicine.

Clearly divided into four main sections, this ready reference covers innate and adaptive immunity, signaling in the immune system, techniques, and immunological disorders.

The articles are uniformly structured for ease of use, carefully designed to aid readers of all levels of expertise. To this end, each chapter includes a glossary of the most important keywords, a concise summary of the article and comprehensive literature references.

This title is essential reading on the hottest topics in immunity today.

Table of Contents:

INNATE AND ADAPTIVE IMMUNITY
Immunology
Superantigens
Antigen Presenting Cells
Cell Mediated Immune Defense
Immunologic Memory

SIGNALING IN THE IMMUNE SYSTEM
Molecular Mediators: Cytokines
Interleukins
Viral Inhibitors and Immune Response Mediators: The Interferons
Interferons, Cytokines and the JAK-STAT Signaling Cascade

TECHNIQUES
Flow Cytometry
Immunoassays
Genetic Engineering of Antibody Molecules

IMMUNOLOLOGICAL DISORDERS
Autoantibodies and Autoimmunity
Synovial Mast Cells in Inflammatory Arthritis
Molecular and Cell Biology of AIDS/HIV

Leukocyte and Stromal Cell Molecules: The CD Markers by Heddy Zola, Bernadette Swart, Ian Nicholson, and Elena Voss Softcover - 581 pages Shipped in CLICK HERE Cat.# JW-IMM2 $148.20 BUY Published:  2007   ISBN:  9780471701323

This unique reference summarizes the structure and function of nearly 600 known leukocyte cell surface molecules and their potential utility as diagnostic and therapeutic targets.

Leukocyte and Stromal Cell Molecules: The CD Markers offers comprehensive coverage of all known CD molecules based on the results of the latest Human Leukocyte Differentiation Antigen (HLDA) Workshops. It begins with an historical introduction, followed by a concise summary of the structure, function, and applications in research, diagnosis and therapy. Next, overviews for each section discuss latest developments, methodologies, and conclusions. The core chapters then offer one-page CD summaries in a standardized format. The summaries present salient features for each molecule, including its structure (accompanied by a diagram), cell and tissue distribution, function, clinical applications, available reagents, and sources for additional information. A CD-ROM with complete proceedings of the Workshop accompanies the book.

This reference is essential for immunologists, haematologists, pathologists, and clinicians. It is also of use for biologists, technicians, professionals in the diagnostic and research reagents industry, and those in diagnostic laboratories.

Table of Contents:

PREFACE
ABBREVIATIONS
ACKNOWLEDGMENTS

PART 1: INTRODUCTION AND BACKGROUND MATERIAL

Chapter 1: Leukocyte Membrane Molecules - An Introduction
Chapter 2: Web Resources for CD Molecules

PART 2: MOLECULE PROFILES CD1–CD350

How to Use the Molecule Profiles
Symbols Used to Denote Domains, Motifs, and Repeats
Molecule Profiles CD1–CD350

INDEX

Sepsis: New Insights, New Therapies, Novartis Foundation Symposium by Novartis Foundation Hardcover - 302 pages Shipped in CLICK HERE Cat.# JW-IMM3 $183.65 BUY Published:  2007   ISBN:  9780470027981

Sepsis: New Insights, New Therapies brings together contributions from an international group of experts in diverse fields to consider how the various pathways implicated in early and late sepsis interact, with a particular emphasis on novel concepts and potential new therapeutic approaches. Topics covered include adaptive immunity, inflammation, neuroendocrinology, bioenergetics and metabolism. Several chapters in the latter half of the book are particularly concerned with treatment strategies involving modulation of the neuroendocrine response.

• Addresses the frequent, but under-recognised condition of sepsis and discusses new ways to prevent and treat it
• Describes numerous pharmacological approaches to therapy for early and late sepsis
• Includes detailed discussion of the various physiological systems implicated in sepsis
• Presents an international perspective, featuring contributions from experts from laboratories worldwide involved in the study of sepsis

Sepsis: New Insights, New Therapies is an invaluable resource for all critical care physicians and researchers. It is also informative reading for immunologists, endocrinologists, neuroendocrinologists, physiologists, and pharmacologists.

Table of Contents:

Chair’s introduction
Discussion

Strategies to modulate cellular energetic metabolism during sepsis
Discussion

Immunostimulation is a rational therapeutic strategy in sepsis
Discussion

Blockade of apoptosis as a rational therapeutic strategy for the treatment of sepsis
Discussion

Modulating neutrophil apoptosis
Discussion

HMGB1 as a potential therapeutic target
Discussion

Poly (ADP-ribose) polymerase activation and circulatory shock
Discussion

Choosing the right substrate
Discussion

Inhibiting glycogen synthase kinase 3β in sepsis
Discussion

Ethyl pyruvate: a novel treatment for sepsis
Discussion

General discussion I

Cytoprotective and anti-inflammatory actions of carbon monoxide in organ injury and sepsis models
Discussion

The hypothalamic pituitary adrenal axis in sepsis
Discussion


Modulating the endocrine response in sepsis: insulin and blood glucose control
Discussion

The neuronal strategy for inflammation
Discussion

Beta-blockade in burns
Discussion

System interactions
Discussion

Protecting the permeability pore and mitochondrial biogenesis
Discussion

Index of contributors
Subject index

Decoding the Genomic Control of Immune Reactions: Novartis Foundation Symposium by Novartis Hardcover - 232 pages Shipped in CLICK HERE Cat.# JW-IMM4 $183.65 BUY Published:  2007   ISBN:  9780470027554

The immune system is one of the most complex systems in the body: Decoding the Genomic Control of Immune Reactions examines new strategies for exploiting the power of genomics to inform studies in immunology.

Part of the prestigious Novartis Foundation series, this title focuses on the new topic of ‘phenomics’, which is the use of genomic and bioinformatic techniques to characterize complex phenotypic systems, such as the immune system.

Contributors to this book explore existing strategies and examine possible new strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve outstanding problems in the treatment of immunological diseases and c