EPIDEMIOLOGY PUBLICATIONS

Epidemiology by Leon Gordis Softcover - 432 pages Shipped in CLICK HERE Cat.# EL-EPI6 $ 50.00 BUY Published:  2008   ISBN:  9781416040026

This popular book is written by the award-winning teacher, Dr. Leon Gordis of the Bloomberg School of Public Health at Johns Hopkins University. He introduces the basic principles and concepts of epidemiology in clear, concise writing and his inimitable style. This book provides an understanding of the key concepts in the following 3 fully updated sections: Section I: The Epidemiologic Approach to Disease and Intervention; Section II: Using Epidemiology to Identify the Causes of Disease; Section III: Applying Epidemiology to Evaluation and Policy. Clear, practical graphs and charts, cartoons, and review questions with answers reinforce the text and aid in comprehension.

• Utilizes new full-color format to enhance readability and clarity.
• Provides new and updated figures, references and concept examples to keep you absolutely current - new information has been added on Registration of Clinical Trials, Case-Cohort Design,
• Case-Crossover Design, and Sources and Impact of Uncertainty ( disease topics include: Obesity, Asthma, Thyroid Cancer, Helicobacter Pylori and gastric/duodenal ulcer and gastric cancer, Mammography for women in their forties) – expanded topics include Person-time.
• Includes STUDENT CONSULT access, allowing you to: o Access the complete contents of the book online, anywhere you go…perform quick searches…and add your own notes and bookmarks. 1. Test yourself with the additional TEST BANK including 200 MCQs, plus complete rationales for all self-assessment Q&A in the print book. . 2. Reference all other STUDENT CONSULT titles you own online, too—all in one place!

Quantitative Methods for Health Research: A Practical Interactive Guide to Epidemiology and Statistics by Nigel Bruce, Daniel Pope, and Debbi Stanistreet Softcover - 552 pages Shipped in CLICK HERE Cat.# JW-EPI7 $ 69.95 BUY Published:  2008   ISBN:  9780470022757

Quantitative Research Methods for Health Professionals: A Practical Interactive Course is a superb introduction to epidemiology, biostatistics, and research methodology for the whole health care community.

Drawing examples from a wide range of health research, this practical handbook covers important contemporary health research methods such as survival analysis, Cox regression, and meta-analysis, the understanding of which go beyond introductory concepts.

The book includes self-assessment exercises throughout to help students explore and reflect on their understanding and a clear distinction is made between a) knowledge and concepts that all students should ensure they understand and b) those that can be pursued by students who wish to do so.

The authors incorporate a program of practical exercises in SPSS using a prepared data set that helps to consolidate the theory and develop skills and confidence in data handling, analysis and interpretation.

Novel and Re-emerging Respiratory Viral Diseases by Novartis Hardcover - 174 pages Shipped in CLICK HERE Cat.# JW-EPI8 $180.90 BUY Published:  2008   ISBN: 9780470065389

The past decade has seen mounting global concern regarding viral outbreaks such as SARS, avian influenza and West Nile virus. In 2004 and 2005, reports of bird-to-human, and possible human-to-human, transmissions of the H5N1 influenza viruses raised fears that these viruses could cause a pandemic on the scale of the Spanish flu pandemic of 1918. Previous to this, a novel coronavirus had been identified as the aetiological agent of the severe acute respiratory syndrome (SARS), a new respiratory viral disease that emerged at the end of 2002 and caused profound disturbances in over 30 countries worldwide in 2003. It is not known whether the SARS coronavirus will re-emerge, especially since its origins and potential reservoir(s) are unresolved. However, these outbreaks have shown that these viruses can emerge in any part of the world at any time.

This book critically evaluates the latest scientific evidence on novel or re-emerging viral diseases and brings together contributions from world experts on this topic, explaining best practice in their area, and discussing lessons learned and how best to collaborate to prevent and control future outbreaks.

Topics covered include:

• the latest advances in virology, particularly in the area of epidemiology
• diagnostics
• animal models for viral infection
• antiviral and vaccine development

Novel and Re-emerging Respiratory Viral Diseases offers a comprehensive and interdisciplinary account of all aspects of the topic, from basic molecular biology to public health issues, and is therefore essential reading for virologists, infectious disease specialists, public health managers, researchers and epidemiologists, as well as those working in vaccine development, pharmaceutical medicine and drug discovery

Table of Contents:

Robert G. Webster Chair’s introduction
Larry J. Anderson and Suxiang Tong

Identification and characterization of novel viruses
Discussion
Edward C. Holmes

The evolution of viral emergence
Discussion
Derek J. Smith, Jan C. de Jong, Alan S. Lapedes, Terry C. Jones, Colin A. Russell, Theo M. Bestebroer, Guus F. Rimmelzwaan, Albert D. M. E. Osterhaus and Ron A. M. Fouchier

Antigenic cartography of human and swine influenza A (H3N2) viruses
Discussion
Gabriele Neumann and Yoshihiro Kawaoka

Influenza pandemics and control
Discussion
J. J. Skehel, S. Wharton, L. Calder and D. Stevens

On the activation of membrane fusion by influenza haemagglutinin
Discussion
Yee Sin Leo

Singapore SARS experience and preparation for future outbreak
Discussion
Yee-Joo Tan

SARS lessons for a young virology laboratory in Singapore
Discussion
Ih-Jen Su

How the SARS experience has helped preparations for future outbreaks: the Taiwan experience, with emphasis on the successful control of institutional outbreak of influenza in 2003/2004 using a stockpile of antivirals
Discussion
General discussion I
Yuelong Shu, Yu Lan, Leying Wen, Ye Zhang, Jie Dong, Xinsheng Zhao, Dayan Wang, Lihong Yao, Xiyan Li, Wei Wang, Xiuping Wang, Qi Wang, Shumin Duan, Jingjing Huang, Lei Yang, Hongjie Yu, Yuanji Guo, Weizhong Yang, Xiyan Xu, Nancy J. Cox, Xiaoping Dong, Yu Wang and Dexin Li

Genetic and antigenic characterization of avian influenza A (H5N1) viruses isolated from humans in Mainland China
Discussion
J. S. M. Peiris and Y. Guan

Emerging infectious diseases and the animal–human interface
Discussion
Erich Hoffmann, Hui-Ling Yen, Rachelle Salomon, Neziha Yilmaz and Robert G. Webster

Transmission and pathogenicity of H5N1 influenza viruses
Discussion
John M. Wood

Development of vaccine for a future influenza pandemic
Discussion

Final discussion
Index of contributors
Subject index

Molecular Epidemiology of Chronic Diseases by Chris Wild, Paolo Vineis, and Seymour Garte Hardcover - 384 pages Shipped in CLICK HERE Cat.# JW-EPI9 $138.20 BUY Published:  2008   ISBN:  9780470027431

With the sequencing of the human genome and the mapping of millions of single nucleotide polymorphisms, epidemiology has moved into the molecular domain. Scientists can now use molecular markers to track disease-associated genes in populations, enabling them to study complex chronic diseases that might result from the weak interactions of many genes with the environment. Use of these laboratory generated biomarker data and an understanding of disease mechanisms are increasingly important in elucidating disease aetiology.

Molecular Epidemiology of Disease crosses the disciplinary boundaries between laboratory scientists, epidemiologists, clinical researchers and biostatisticians and is accessible to all these relevant research communities in focusing on practical issues of application, rather than reviews of current areas of research.

• Covers categories of biomarkers of exposure, susceptibility and disease
• Includes chapters on novel technologies: genomics, transcriptomics, proteomics and metabonomics, which are increasingly finding application in population studies
• Emphasizes new statistical and bioinformatics approaches necessitated by the large data sets generated using these new methodologies
• Demonstrates the potential applications of laboratory techniques in tackling epidemiological problems while considering their limitations, including the sources of uncertainty and inaccuracy
• Discusses issues such as reliability (compared to traditional epidemiological methods) and the timing of exposure
• Explores practical elements of conducting population studies, including biological repositories and ethics

Molecular Epidemiology of Disease provides an easy-to-use, clearly presented handbook that allows epidemiologists to understand the specifics of research involving biomarkers, and laboratory scientists to understand the main issues of epidemiological study design and analysis. It also provides a useful tool for courses on molecular epidemiology, using many examples from population studies to illustrate key concepts and principles.

Table of Contents:

Contributors
Artist statement
Acknowledgements

1. Introduction: why molecular epidemiology

References

2. Study design
2.1. Introduction: study design at square one
2.2. Epidemiological measures
2.3. Bias

Bias in screening practices

2.4. More on confounding
2.5. Specificities of molecular epidemiology design

Special designs in molecular epidemiology
Bias
Selection bias related to sample collection
Confounding and population admixture
Mendelian randomization

2.6. Conclusions

References
Essential reading

3. Molecular epidemiological studies that can be nested within cohorts
3.1. Introduction
3.2. Case-cohort studies

Design and calculable measures of effect
Case-cohort designs offer flexibility
Analytical complexity

3.3. Nested case-control studies

Design and calculable measures of effect
Matching
Counter-matching
Individuals may be included in the analyses multiple times

3.4. Considerations regarding biomarker analyses in case-cohort and nested case-control studies

Batch effects
Batch effects and case-cohort studies
Batch effects and nested case-control studies
Storage effects
Storage effects and case-cohort studies
Storage effects and nested case-control studies
Freeze-thaw cycles
Freeze-thaw cycles and case-cohort studies
Freeze-thaw cycles and nested case-control studies

3.5. Conclusion

References

4. Family studies, haplotypes and gene association studies
4.1. Introduction
4.2. Family studies

Is there an increased risk of disease in relatives of cases?
Is the familial aggregation due to genes or environment?
What is the genetic mechanism?
Where is the gene?
Linkage analysis
Example

4.3. Genetic association studies

Genetic case-control studies
Bias and confounding
Family-based study designs
Haplotypes
Reconstructing haplotypes
Association studies with haplotypes
SNP selection
Whole-genome association studies

4.4. Discussion

References

5. Individual susceptibility and gene-environment interaction

5.1. Individual susceptibility
5.2. Genetic susceptibility
5.3. Metabolic susceptibility genes
5.4. Study designs
5.5. Gene-environment interaction
5.6. Exposure dose effects in gene-environment interactions
5.7. Mutational effects of gene-environment interactions
5.8. Conclusions

References

6. Biomarker validation
6.1. Validity and reliability
6.2. Biomarker variability
6.3. Measurement of variation
6.4. Other issues of validation
6.5. Measurement error

Sources of laboratory measurement error

6.6. Blood collection for biomarkers
6.7. Validation of high-throughput techniques

References

7. Exposure assessment
7.1. Introduction
7.2. Initial considerations of an exposure assessment strategy
7.3. Exposure pathways and routes
7.4. Exposure dimensions
7.5. Exposure classification, measurement or modelling
7.6. Retrospective exposure assessment
7.7. Validation studies
7.8. Quality control issues

References

8. Carcinogen metabolites as biomarkers
8.1. Introduction
8.2. Overview of carcinogen metabolism
8.3. Examples of carcinogen metabolite biomarkers

Total NNAL (NNAL plus its glucuronides): an established biomarker of exposure to the tobacco-specific lung carcinogen NNK
Phenanthrene metabolites: developing biomarkers of PAH exposure and metabolism
Other examples of carcinogen metabolite biomarkers

8.4. Summary

Acknowledgement
References

9. Biomarkers of exposure: adducts
9.1. Introduction
9.2. Methods for adduct detection
9.3. Adducts identified in human tissue

Sources of DNA for biomonitoring

9.4. Adducts as biomarkers of occupational and environmental exposure to carcinogens
9.5. Smoking-related adducts
9.6. DNA adducts in prospective studies

DNA adducts in human DNA repair studies
Correlations between DNA and protein adducts

9.7. Conclusions

References

10. Biomarkers of mutation and DNA repair capacity
10.1. Introduction
10.2. Classification of mutations
10.3. Mutations in molecular epidemiology
10.4. DNA repair
10.5. Classes of DNA repair
10.6. Common assays to measure DNA repair capacity

Cellular biomarkers for DNA repair
Assays based on induced DNA damage
Mutagen sensitivity assay
Comet assay
Unscheduled DNA synthesis (UDS)
Host cell reactivation assay
Other assays
OGG activity
Combination studies

10.7. Integration of DNA repair assays into epidemiological studies

Study design
Assay variability
Biological plausibility

10.8. Genetic markers for DNA repair capacity

References

11. High-throughput techniques - genotyping and genomics
11.1. Introduction
11.2. Background
11.3. SNP databases
11.4. Study types
11.5. Study design
11.6. Genotyping technologies
11.7. Sample and study management and QC

DNA extraction and normalization
DNA arraying
Robotics and plate sealing
QC steps

11.8. After the association has been proved - what next?

References

12. Proteomics and molecular epidemiology
12.1. Introduction
12.2. General considerations
12.3. Sample selection
12.4. Proteomics technologies

Protein identification using mass spectrometry
Sample fractionation
Sample enrichment
Sample depletion
Quantification of proteins and peptides
Validation

12.5. Illustrative applications
12.6. Final considerations

References

13. Exploring the contribution of metabolic profiling to epidemiological studies
13.1. Background
13.2. Cancer
13.3. Cardiovascular disease
13.4. Neurodegenerative disorders
13.5. The way forward

Acknowledgements
References

14. Univariate and multivariate data analysis
14.1. Introduction

Overview
Terminology and definitions
A priori model assumptions
Initial data exploration

14.2. Univariate analysis

Simple linear regression
Multiple linear regression
Path diagram
Simple linear regression
Multiple linear regression

14.3. Generalized linear models
14.4. Multivariate methods

Multilevel modelling (MLM)
Structural equation modelling (SEM)
Latent growth curve modelling (LGCM)
Flexibility of LGCM

14.5. Conclusions

Acknowledgements
References

15. Meta-analysis and pooled analysis - genetic and environmental data
15.1. Introduction
15.2. Meta analysis

Database searching, eligibility criteria and data extraction
Graphical summaries
Summary estimates and assessment of heterogeneity
Assessing publication bias

15.3. Pooled analysis
15.4. Issues in pooled analysis of epidemiological studies involving molecular markers

Choice of study design
Planning of the study
Selection of studies
Data request
Evaluation of the validity of the study
Data standardization
Heterogeneity among studies
Publication bias
Ethical issues
References

16. Analysis of complex datasets
16.1. Introduction
16.2. Gene-environment interaction
16.3. Gene-gene interaction
16.4. Statistical interaction

Detecting statistical patterns of interaction
Decision trees, classification trees and random forests
Multifactor dimensionality reduction (MDR)
Statistical interpretation of interaction models

16.5. Case study: bladder cancer
16.6. Genome-wide analysis

A filter strategy for genome-wide analysis
A wrapper strategy for genome-wide analysis

16.7. Summary

Acknowledgements
References

17. Some implications of random exposure measurement errors in occupational and environmental epidemiology
17.1. Introduction
17.2. Individual-based study

Regression analysis
Estimating sample sizes for a specified bias

17.3. Group-based studies

Exposure model with a random group effect
Health-outcome model
Regression analysis
Estimating sample sizes
Adjusting estimated regression coefficients for attenuation bias

17.4. Comparing biases for individual-based and group-based studies
17.5. Conclusions

Acknowledgement
References

18. Bioinformatics
18.1. Introduction
18.2. Database resources
18.3. Data analysis

Data mining using R
Data mining using Weka
Data mining using Orange
Data mining using multifactor dimensionality reduction
Interpreting data mining results

18.4. The future

Acknowledgements
References

19. Biomarkers, disease mechanisms and their role in regulatory decisions

19.1. Introduction
19.2. Hazard identification and standard setting
19.3. Risk characterization: individuals and populations
19.4. Monitoring and surveillance
19.5. What to regulate: exposures or people’s access to them?
19.6. Conclusion

References

20. Biomarkers as endpoints in intervention studies
20.1. Introduction: why are biomarkers needed in intervention studies?
20.2. Identification and validation of biomarkers
20.3. Use of biomarkers in making health claims
20.4. Biomarkers of study compliance
20.5. Biomarkers that predict the risk of disease
20.6. Biomarkers relevant to more than one disease

Oxidative stress
Inflammation
Cancer
Cardiovascular disease
Diabetes

20.6. Biomarkers that predict the optimization of health or performance
20.7. Conclusions

References

21. Biological resource centres in molecular epidemiology: collecting, storing and analysing biospecimens

21.1. Introduction
21.2. Obtaining and collecting biospecimens

Planning a collection
Types of biospecimens
Collecting biospecimens

21.3. Annotating, storing and processing biospecimens

Identifying biospecimens
Storage facilities
Labelling
Conditions of storage
Laboratory processing and shipping
BRC database
Quality assurance and quality control

21.4. Analysing biomarkers
21.5. Conclusions

References

22. Molecular epidemiology and ethics: biomarkers for disease susceptibility
22.1. Introduction
22.2. Ethical aspects in biomarker development for disease susceptibility

Variation of biomarkers
Ethical aspects of genetic biomarkers for susceptibility
Quality of research

22.3. Ethical aspects of biobanking

Management of biobanks
Consent practice
Storage and distribution of samples and data
Populations, individuals and autonomy

22.4. Molecular epidemiology and society

Science, money and public trust
Communication
Education in ethics

22.5. Conclusions

Acknowledgements
References

23. Biomarkers for dietary carcinogens: the example of heterocyclic amines in epidemiological studies
23.1. Introduction
23.2. Intake assessment of HCAs
23.3. HCA metabolism

Urinary biomarkers as a measure of internal exposure
Adducts as a measure of biologically effective dose

23.4. Conclusions and future research

References

24. Practical examples 2: Hormones
24.1. Introduction
24.2. Hormone measurements for large-scale epidemiological studies
24.3. Laboratory methods

Reference methods
Direct immunoassays
24.4. Validation and reproducibility of hormone measurements
24.5. Sample collection and long-time storage
24.6. Does a single hormone measurement represent long-term exposure?
24.7. Interpretation of measurements of circulating hormones
24.8. Conclusions
References

25. Aflatoxin, hepatitis B virus and liver cancer: a paradigm for molecular epidemiology

25.1. Introduction
25.2. Defining molecular biomarkers
25.3. Validation strategy for molecular biomarkers
25.4. Development and validation of biomarkers for human hepatocellular carcinoma

Early aetiological studies of aflatoxin, HBV and HCC
Development of methodologies for measuring biomarkers
Relationship of aflatoxin biomarkers to exposure and disease in experimental animals
Modulation of biomarkers and disease in animal chemoprevention studies
Validation of aflatoxin biomarkers in cross-sectional studies in human populations
Longitudinal study of biomarkers in humans
Case-control and cohort studies
Clinical trials for reducing aflatoxin exposure and internal dose

25.5. Susceptibility
25.6. Biomarkers to elucidate mechanisms of interaction
25.7. Early detection biomarkers for HCC
25.8. Summary and perspectives for the future

Acknowledgements
References

26. Complex exposures - Air Pollution

26.1. Introduction
26.2. Personal monitoring of external dose
26.3. Biomarkers of internal dose and air pollutants

PAH metabolites
Benzene and metabolites

26.4. Biomarkers of biologically effective dose

Mechanisms of oxidative stress induced by particles and other air pollutants
Oxidative stress-induced DNA damage and repair
Air pollution exposure and biomarkers of oxidative stress and DNA damage

26.5. Biomarkers of biological effects

Inflammation
Cell damage
Gene expression
Cytogenetic markers
Mutations

26.6. Genetic susceptibility and oxidative stress related to air pollution
26.7. Conclusion

Acknowledgements
References
Index

Avian Influenza by David E. Swayne Hardcover - 628 pages Shipped in CLICK HERE Cat.# JW-EPI10 $162.70 BUY Published:  2008   ISBN:  9780813820477

Avian Influenza provides the first comprehensive guide covering the full spectrum of this complex and increasingly high-profile disease, its history and its treatment and control. All aspects of avian influenza are dealt with in depth, systematically covering biology, virology, diagnostics, ecology, epidemiology, clinical medicine, and the control. The book fuses coverage of the latest discoveries in the basic sciences with a practical approach to dealing with the disease in a clinical setting, and providing instruction and guidance for veterinarians and government animal health officials encountering this disease in the field.

Avian Influenza provides the reader with a global perspective, bringing together chapters written by leading animal health researchers and veterinarians with significant experience working with this disease. Providing a summary and synthesis of important data and research on this virus, its impact on both wild and domesticated birds, and approaches to controlling the spread of the disease, Avian Influenza will be an invaluable resource for all veterinarians, scientists, animal health professionals, and public health officials dealing with this virus.

• Covers full range of topics within avian influenza in one comprehensive and authoritative text
• Provides a summarization of peer-reviewed and empirical data on avian influenza viruses, the infection and diseases they cause
• Discusses strategies used in control of the disease
• Leading experts are drawn together to provide an international and multi-disciplinary perspective
• Fuses latest developments in basic scientific research with practical guidance on management of the disease

Table of Contents:

Contributors List
Foreword
Preface

1. Influenza A Virus
2. Molecular Determinants of Pathogenicity for Avian Influenza Viruses
3. Ecology of Avian Influenza in Wild Birds
4. Epidemiology of Avian Influenza in Agricultural and Other Man-Made Systems
5. Pathobiology of Avian Influenza Virus Infections in Birds and Mammals

Color Plate Section

6. The Global Nature of Avian Influenza
7. The Beginning and Spread of Fowl Plague (H7 High Pathogenicity Avian Influenza) Across Europe and Asia (1878-1955)
8. High Pathogenicity Avian Influenza in the Americas
9. Highly Pathogenic Avian Influenza Outbreaks in Europe, Africa and Asia since 1959, Excluding the Asian H5N1 Virus Outbreaks
10. Avian Influenza in Australia
11. Multi-Continental Epidemic of H5N1 High Pathogenicity Avian Influenza Virus (1996-2007)
12. Avian Influenza Control Strategies
13. Avian Influenza Diagnostics and Surveillance Methods
14. Humane Mass Depopulation as an Effective Measure For Disease Control Purposes
15. Methods for Disposal of Poultry Carcasses
16. Farm and Regional Biosecurity Practices
17. Farm Biosecurity Risk Assessment and Audits
18. Methods for Inactivation of Avian Influenza Virus in the Environment
19. Vaccines, Vaccination and Immunology for Avian Influenza Viruses in Poultry
20. Public Health Implications of Avian Influenza Viruses
21. The Role of Educational Programs in the Control of Avian Influenza
22. Trade and Food Safety Aspects for Avian Influenza Viruses
23. Control of Low Pathogenicity Avian Influenza
24. The Economics of Avian Influenza
25. Global Strategy for Highly Pathogenic Avian Influenza: Progressive Control and Eradication, and Post-Outbreak Recovery
Index

Handbook of Tuberculosis: Clinics, Diagnostics, Therapy, and Epidemiology by Stefan H. E. Kaufmann, and Paul van Helden Hardcover - 311 pages Shipped in CLICK HERE Cat.# JW-EPI11 $180.90 BUY Published:  2008   ISBN:  9783527318889

Tuberculosis (TB), a deadly airborne disease caused by the bacterium Mycobacterium tuberculosis, takes the lives of almost 2 million people each year and is considered to be the most common infectious disease in the world. However, thanks to the efforts of researchers such as the volumes’ lead editor, Dr. Stefan H. E. Kaufmann, there have been several recent advances in fighting the disease.

Dr. Stefan Kaufmann, the Founding Director of the Max Planck Institute for Infection Biology in Berlin and Professor of Microbiology and Immunology at the Charité at the Humboldt University, Berlin, has published more than 600 scientific articles and currently serves as President of the European Federation of Immunological Societies and Chair of the Immunology Division of the American Society of Microbiology. Dr. Kaufmann is considered the world's leading expert in the field of tuberculosis.

The Handbook of Tuberculosis, which explores the causes and available treatments of the widespread infection as well as current research into vaccination, is divided into three separate volumes covering different areas of study. Each volume provides an essential resource to molecular and cell biologists, bacteriologists, immunologists, pathologists and pathophysiologists, clinicians and those working in the pharmaceutical industry and interested in world health.

Volume 1: Molecular Biology and Biochemistry highlights the molecular mechanisms of tuberculosis.

Volume 2: Immunology and Cell Biology presents the pre-eminent resource for all aspects of cell biology and immunology of tuberculosis, including vaccine development.

Volume 3: Clinics, Diagnostics, Therapy and Epidemiology introduces a comprehensive overview of clinical aspects of tuberculosis, including drug resistance, epidemiological aspects and clinical trials. It is co-edited by Dr. Paul van Helden, Professor of Medical Biochemistry at Stellenbosch University, South Africa, Director of Laboratory Research for the Desmond Tutu Tuberculosis Centre and former President of the South African Society of Biochemistry and Molecular Biology.

Table of Contents:
Clinics Diagnostics Therapy Epidemiology: Introduction
Global Epidemiology of Tuberculosis
Surveillance Studies and Interpretation
Molecular Epidemiology of M. tuberculosis
Diagnosis of M. tuberculosis: Clinical
Clinical Disease (with and without HIV)
Management of Tuberculosis Patients
Chemotherapy
New Drugs and Clinical Drug Trials
Latency
Drug Resistance in Clinical Context
Novel Drug Treatment Strategies - Co-infections
Modeling
BCG Vaccination

The Metabolic Syndrome: Epidemiology, Clinical Treatment, and Underlying Mechanisms by Barbara C. Hansen Hardcover - 402 pages Shipped in CLICK HERE Cat.# DA-EPI5 $209.95 BUY Published:  2008   ISBN:  9781588297389

Metabolic syndrome is the most common clinical disorder, affecting as many as 60% of middle-aged and older adults. This book includes updated clinical views on metabolic syndrome; its definition and current and current and future treatment options; and critical evaluation of the current status of each of the syndrome components, including the latest knowledge of casual mechanisms. It is anticipated that this book will be of value to all of those seeking a comprehensive update on the metabolic syndrome. It will provide a broad basis for advancing research in the multiple intersecting disciplines encompassed by the metabolic syndrome.

Key Features: Covers the most important clinical and bench science aspects of the metabolic syndrome, Co-Editor Dr. Bray is one of the leading figures in the world on obesity and metabolic syndrome.

Contents: Metabolic Syndrome: to be or not to be. The Role of Obesity in Insulin Resistance: Epidemiological and metabolic aspects. Treatment of the Metabolic Syndrome with Weight Loss, Exercise, Hormones and Surgery. Insulin Resistance, Metabolic Syndrome, and Cardiovascular Disease: an epidemiological perspective. The Sympatho-Adrenal System in Metabolic Syndrome. Insulin Action and Endothelial Function. Macro and Micro Vascular Disease in an Insulin Resistant - Pre-diabetic Animal Model (the JCR:LA-cp Rat. High Sensitivity C-reactive protein (Hs-CRP) in Metabolic Syndrome. Insulin Signaling in Adipocytes and the Role of Inflammation. Insulin Resistance and Dyslipidemia. Pancreatic Islet Pathophysiology and Pathology in Obesity. Glucagon Peptides and Insulin Sensitivity. The Relationship between the Insulin Receptor Substrates and Metabolic Disease. Insulin Resistance and Inhibitors of the Insulin Receptor Tyrosine Kinase. Fat Feeding and Muscle Fat Deposition Eliciting Insulin Resistance: an update. Alternations in Atypical Protein Kinase-C (APK-C) Activation in Insulin Resistance Syndrome. The Liver's Role in Insulin Action and Resistance.