An interactive, menu-driven and easy to use program which simulates a number of experiments which can be performed on the 'in situ' heart of a pithed frog.High-resolution simulations of contractions of the frog heart, derived from real data, are presented on a scrolling display to simulate a chart recorder. The trace may be paused to facilitate measurement of heart rate or to assess changes in the amplitude of atrial or ventricular contraction.

Experiments include:

• Interpretation of a typical trace;
• the effects of adrenaline;
• the effects of acetylcholine (with physostigmine or atropine);
• the effects of temperature;
• refractory period;
• electrical conduction through the heart (Stannius ligatures).

Each experiment is prefaced by introductory text and includes an experiment guide and assignments.

System Requirements: Windows: Intel Pentium II 450MHz or faster processor (or equivalent), 128MB of RAM; Microsoft Windows 98, Windows Me, Windows 2000, Windows XP or Windows Server 2003 Macintosh: PowerPC G3 500MHz or faster processor, 128MB of RAM; Mac OS X v.10.1.x, 10.2.x, 10.3.x, or 10.4.x

Recommended browser software: Windows:  Internet Explorer; Macintosh:  Safari or Firefox; Both: Adobe Flash Player plug-in, version 8 or higher.

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