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Nerve Block - A nerve block involves infiltrating local anaesthetic around a nerve to interrupt conduction (temporarily). Small fibres (particularly pain fibres) are most affected. Larger fibres are affected to a lesser degree (hence touch sensation may remain). What advantage does a nerve block have over direct infiltration? Appropriate sites for access to nerves are determined by relationships to anatomical landmarks and potential hazards (e.g accompanying vessels and neighbouring vital organs). Landmarks directly observed or palpated, coupled with knowledge of anatomy and its variations, are vital for correct placement.